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Review
. 2021 Dec 15;7(1):16.
doi: 10.1186/s40733-021-00082-0.

The link between atopic dermatitis and asthma- immunological imbalance and beyond

Martina Yaneva  1 , Razvigor Darlenski  2   3
Affiliations
Review

The link between atopic dermatitis and asthma- immunological imbalance and beyond

Martina Yaneva et al. Asthma Res Pract. .

Abstract

Atopic diseases are multifactorial chronic disturbances which may evolve one into another and have overlapping pathogenetic mechanisms. Atopic dermatitis is in most cases the first step towards the development of the atopic march and represents a major socio-economic burden in the industrialized countries. The treatment of atopic diseases is often long-lasting and in some cases with lower effectiveness than expected.In order to prevent the development of the atopic march, the links between the atopic diseases have to be understood. The aim of this review is to present some major points outlining the link between atopic dermatitis and asthma, through a research in the medical literature from recent years.Stratifying patient populations according to the clinical phenotype of their disease and according to specific measurable values (biomarkers) can help to establish the main etiopathogenetic mechanisms of the disease in these populations. This will add predictive value for the evolution of the disease, and will allow the use and research of more targeted therapy in order to stop this evolution and comorbidities.

Keywords: Asthma; Atopic march; Atopy; Comorbidities; Endotypes; Phenotypes.

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Conflict of interest statement

The authors have no conflict of interest to declare

References

    1. Weidinger S, Novak N. Atopic dermatitis. Lancet. 2016;387(10023):1109–1122. doi: 10.1016/S0140-6736(15)00149-X. - DOI - PubMed
    1. Karimkhani C, Dellavalle RP, Coffeng LE, Flohr C, Hay R, Langan S, et al. Global skin disease morbidity and mortality: an update from the Global Burden of Disease study 2013. JAMA Dermatol. 2017;153(5):406–412. doi: 10.1001/jamadermatol.2016.5538. - DOI - PMC - PubMed
    1. Weidinger S, Beck LA, Bieber T, Kabashima K, Irvine A. Atopic dermatitis Nat Rev Dis Primers. 2018;4(1):1. doi: 10.1038/s41572-018-0001-z. - DOI - PubMed
    1. Network GA. The Global Asthma Report, Auckland, New Zealand. (2018)
    1. Unsworth J, Ali RF. Does this patient have atopic asthma? Clin Med (Lond) 2011;11(4):376–380. doi: 10.7861/clinmedicine.11-4-376. - DOI - PMC - PubMed

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