Combination therapy of infliximab and thiopurines, but not monotherapy with infliximab or vedolizumab, is associated with attenuated IgA and neutralisation responses to SARS-CoV-2 in inflammatory bowel disease

Judith Wellens^#^{1

2}, Matthew Edmans^#^{2

3}, Uri Obolski^{4

5}, Colleen Gc McGregor², Peter Simmonds³, Marc Turner⁶, Lisa Jarvis⁶, Donal Skelly^{3

7}, Susanna Dunachie^{8

9

10}, Eleanor Barnes^{2

3}, David W Eyre^{8

11}, Jean-Frederic Colombel¹², Serre-Yu Wong¹³, Paul Klenerman^{2

3}, James O Lindsay¹⁴, Jack Satsangi², Craig P Thompson^{15

16}

Affiliations

¹ Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
² Translational Gastroenterology Unit, University of Oxford, Oxford, UK.
³ Nuffield Department of Medicine, University of Oxford, Oxford, UK.
⁴ School of Public Health, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
⁵ Porter School of Environmental and Earth Sciences, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv, Israel.
⁶ National Microbiology Reference Unit, Scottish National Blood Transfusion Service, Edinburgh, Edinburgh, UK.
⁷ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
⁸ Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
⁹ Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
¹⁰ Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
¹¹ Nuffield Department of Population Health, University of Oxford, Oxford, UK.
¹² Department of Gastroenterology, Mount Sinai School of Medicine, New York, New York, USA.
¹³ The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
¹⁴ Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.
¹⁵ Warwick Medical School, University of Warwick, Coventry, UK craigpeterthompson@gmail.com.
¹⁶ Department of Zoology, University of Oxford, Oxford, UK.

^# Contributed equally.

PMID: 34911744
DOI: 10.1136/gutjnl-2021-326312

Combination therapy of infliximab and thiopurines, but not monotherapy with infliximab or vedolizumab, is associated with attenuated IgA and neutralisation responses to SARS-CoV-2 in inflammatory bowel disease

Judith Wellens et al. Gut. 2022 Sep.

. 2022 Sep;71(9):1919-1922.

doi: 10.1136/gutjnl-2021-326312. Epub 2021 Dec 15.

Authors

Affiliations

¹ Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium.
² Translational Gastroenterology Unit, University of Oxford, Oxford, UK.
³ Nuffield Department of Medicine, University of Oxford, Oxford, UK.
⁴ School of Public Health, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
⁵ Porter School of Environmental and Earth Sciences, Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv, Israel.
⁶ National Microbiology Reference Unit, Scottish National Blood Transfusion Service, Edinburgh, Edinburgh, UK.
⁷ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
⁸ Department of Microbiology/Infectious Diseases, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.
⁹ Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
¹⁰ Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
¹¹ Nuffield Department of Population Health, University of Oxford, Oxford, UK.
¹² Department of Gastroenterology, Mount Sinai School of Medicine, New York, New York, USA.
¹³ The Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA.
¹⁴ Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK.
¹⁵ Warwick Medical School, University of Warwick, Coventry, UK craigpeterthompson@gmail.com.
¹⁶ Department of Zoology, University of Oxford, Oxford, UK.

^# Contributed equally.

PMID: 34911744
DOI: 10.1136/gutjnl-2021-326312

No abstract available

Keywords: IBD; immune response; infectious disease.

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Conflict of interest statement

Competing interests: JS has received lecture fees from Takeda and from the Falk Foundation.

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Combination therapy of infliximab and thiopurines, but not monotherapy with infliximab or vedolizumab, is associated with attenuated IgA and neutralisation responses to SARS-CoV-2 in inflammatory bowel disease

Affiliations

Combination therapy of infliximab and thiopurines, but not monotherapy with infliximab or vedolizumab, is associated with attenuated IgA and neutralisation responses to SARS-CoV-2 in inflammatory bowel disease

Authors

Affiliations

Conflict of interest statement

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MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous