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Comment
. 2021 Dec 15;81(24):6071-6073.
doi: 10.1158/0008-5472.CAN-21-3603.

Macrophage-Targeting by CSF1/1R Blockade in Pancreatic Cancers

Won Jin Ho  1 , Elizabeth M Jaffee  1
Affiliations
Comment

Macrophage-Targeting by CSF1/1R Blockade in Pancreatic Cancers

Won Jin Ho et al. Cancer Res. .

Abstract

Published in Cancer Research in 2014, Zhu and colleagues achieved a mechanistic leap in our understanding of cancer-associated macrophage biology with their proof-of-concept study showing that macrophage-specific targeting, via blocking colony-stimulating factor-1 (CSF1) signaling through its cognate receptor CSF1R, synergized with checkpoint immunotherapy to enhance antitumor immunity in mouse models of pancreatic cancer. Here, we reflect on the critical set of observations presented in this study and how the study's findings fueled the subsequent efforts to translate CSF1/1R-specific and other tumor-associated macrophage modulating therapies into the clinic.See related article by Zhu and colleagues, Cancer Res 2014;74:5057-69.

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Figures

Figure 1.
Figure 1.
Key efforts investigating the CSF1/1R axis and its role in cancer. Timeline, research leading up to and following the landmark study published by Zhu and colleagues in Cancer Research in 2014 (5).
See this image and copyright information in PMC

Comment on

References

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