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Review
. 2021 Dec 6:2021:5541768.
doi: 10.1155/2021/5541768. eCollection 2021.

Systematic Review of Tongxinluo Capsule on the Therapeutic Effect and Hemorheology of Patients with Transient Ischemic Attack

Peng Yang  1 , Peng Liu  1 , Ruijin Yang  1
Affiliations
Review

Systematic Review of Tongxinluo Capsule on the Therapeutic Effect and Hemorheology of Patients with Transient Ischemic Attack

Peng Yang et al. Evid Based Complement Alternat Med. .

Abstract

Objectives: This study aims to systematically evaluate the clinical efficacy of Tongxinluo capsule in the treatment of transient ischemic attack (TIA) and its effect on hemorheology, thereby providing scientific basis for clinical decision making.

Methods: A comprehensive and systematic literature retrieval was conducted in the CNKI, Wanfang database, SinoMed, EMbase, and PubMed to screen the randomized controlled trials (RCTs) of Tongxinluo capsule in the treatment of TIA. The retrieval time was from the inception of each database to September 10, 2020. Endnote X9 was used to screen the literature. Cochrane Collaboration tool for assessing risk of bias was used to evaluate the quality of the included studies. Stata16.0 statistical software was used for meta-analysis.

Results: A total of 12 RCTs were included, involving 946 subjects. (1) The clinical efficacy of the Tongxinluo group was better than that of the control group (RR = 1.19, 95% CI (1.09, 1.30), P ≤ 0.001). (2) The hemorheological characteristics of the Tongxinluo group were significantly improved compared with those of the control group (whole blood high shear viscosity: SMD = -1.61, 95% CI (-1.89, -1.34); P ≤ 0.001, whole blood low shear viscosity: SMD = -1.06, 95% CI (-1.31, -0.80), P ≤ 0.001, fibrinogen: SMD = -1.12, 95% CI (-1.94, -0.29), P = 0.008, plasma specific viscosity: SMD = -1.00, 95% CI (-1.69, -0.31), P = 0.004, and hematocrit: SMD = -1.47, 95% CI (-2.16, -0.77), P ≤ 0.001). (3) There was no significant difference in the incidence of adverse reactions between the Tongxinluo group and control group (RR = 7.76, 95% CI (0.98, 61.28), P = 0.052).

Conclusion: Tongxinluo capsule is superior to conventional treatment in improving clinical overall response rate and hemorheological indexes and is relatively safe. Due to the deficiencies of the existing studies, more high-quality studies with rigorous design are required for further verification.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Steps of literature screening.
Figure 2
Figure 2
Bar graph of bias risk.
Figure 3
Figure 3
Risk of bias summary.
Figure 4
Figure 4
Forest plot of overall response rate.
Figure 5
Figure 5
Sensitivity analysis.
Figure 6
Figure 6
Forest plot of whole blood high shear viscosity.
Figure 7
Figure 7
Forest plot of whole blood low shear viscosity.
Figure 8
Figure 8
Forest plot of fibrinogen.
Figure 9
Figure 9
Forest plot of plasma specific viscosity.
Figure 10
Figure 10
Forest plot of hematocrit.
Figure 11
Figure 11
Forest plot of adverse reaction.
Figure 12
Figure 12
Funnel plot of overall response rate.
See this image and copyright information in PMC

References

    1. Easton J. D., Saver J. L., Albers G. W., et al. Definition and evaluation of transient ischemic attack. Stroke . 2009;40(6):2276–2293. doi: 10.1161/strokeaha.108.192218. - DOI - PubMed
    1. Kissela B. M., Khoury J. C., Alwell K., et al. Age at stroke: temporal trends in stroke incidence in a large, biracial population. Neurology . 2012;79(17):1781–1787. doi: 10.1212/wnl.0b013e318270401d. - DOI - PMC - PubMed
    1. Gao C., Li W., Lin B., Zhan T. T., Lin Z. C. Predictive ability of ABCD∼2 score for mid-term cerebral infarction and death after transient cerebral ischemia. Chinese Journal of Neurology . 2011;10(9):896–899.
    1. Yin S. H. Analysis of the efficacy and safety of aspirin combined with clopidogrel in the treatment of intractable transient ischemic attack. Electronic Journal of Clinical Medical Literature . 2017;4(68):13293–13294.
    1. Yang F. X., Wang N. Research progress of hemorheology in ischemic cerebrovascular disease. Journal of Anhui Vocational and Technical College of Health . 2015;14(04):44–47.

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