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Meta-Analysis
. 2021 Dec 6:2021:1284149.
doi: 10.1155/2021/1284149. eCollection 2021.

Combination use of core decompression for osteonecrosis of the femoral head: A systematic review and meta-analysis using Forest and Funnel Plots

Linghanqing Wang  1 , XuRong Tian  1 , Keda Li  1 , Chunlei Liu  2
Affiliations
Meta-Analysis

Combination use of core decompression for osteonecrosis of the femoral head: A systematic review and meta-analysis using Forest and Funnel Plots

Linghanqing Wang et al. Comput Math Methods Med. .

Retraction in

Abstract

Objective: This study evaluated the efficacy and safety of CD combined with bone marrow stem cells in the treatment of femoral head necrosis by systematic review and meta-analysis. Methodology. PubMed, The Cochrane Library, Embase, CNKI, Google Scholar and MEDLINE, etc. databases were searched for clinical randomized controlled trials (RCTs) comparing core decompression combined with autologous bone marrow mesenchymal stem cells versus core decompression alone in the treatment of femoral head necrosis. The retrieval period is from the establishment of each database to May 20, 2021. After literature was extracted and literature quality was evaluated, meta-analysis was conducted by using RevMan5.3 software.

Results: A total of 420 osteonecrosis of the femoral head 452 patients' data were collected from all studies. Compared with the core decompression alone group, the CD combined with bone marrow stem cell showed marked reduction in the Visual analog scale (VAS), enhanced Harris hip score (HHS) at 12 months and 24 months, slowed down the progression of the disease, decreased the number of hips conversed to total hip arthroplasty (THA) in the future.

Conclusion: Core decompression therapy is a very effective and safe treatment process used for ONFH. Moreover, CD combined autologous bone marrow stem cell transplantation can improve the survival rate of the necrotic head, reduce hip pain and delay the disease progression, the rate of THA postoperatively.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart for Selection of studies for meta-analysis.
Figure 2
Figure 2
The risk of bias of randomized trials included in the meta-analysis.
Figure 3
Figure 3
Risk of bias summary review authors' judgments about each risk of bias item for each included study.
Figure 4
Figure 4
Forest plot of the Visual analogue scale (VAS) score of patient's hip joint pain.
Figure 5
Figure 5
Forest plot of the Harris hip score (HHS) of patient's hip joint function at 12 months and 24 months.
Figure 6
Figure 6
Forest plot of disease progression shown by ARCO/FICAT staging.
Figure 7
Figure 7
Forest plot of the rate of total hip arthroplasty (THA).
Figure 8
Figure 8
The funnel plot of each observation indicator postoperatively. Note: Figure A-D is VAS, HHS, Disease progression, the rate of THA.
See this image and copyright information in PMC

References

    1. Lieberman J. R., Berry D. J., Mont M. A., et al. Osteonecrosis of the hip. The Journal of Bone and Joint Surgery-American Volume . 2002;84(5):834–853. doi: 10.2106/00004623-200205000-00023. - DOI
    1. Mont M. A., Jones L. C., Hungerford D. S. Nontraumatic Osteonecrosis of the Femoral head: ten years later. The Journal of Bone & Joint Surgery . 2006;88(5):1117–1132. doi: 10.2106/JBJS.E.01041. - DOI - PubMed
    1. Mont M. A., Ragland P. S., Etienne G. Core Decompression of the Femoral Head for Osteonecrosis Using Percutaneous Multiple Small-Diameter Drilling. Clinical Orthopaedics and Related Research . 2004;429:131–138. doi: 10.1097/01.blo.0000150128.57777.8e. - DOI - PubMed
    1. Zhang H.-J., Liu Y. W., du Z. Q., et al. Therapeutic effect of minimally invasive decompression combined with impaction bone grafting on osteonecrosis of the femoral head. European Journal of Orthopaedic Surgery & Traumatology . 2013;23(8):913–919. doi: 10.1007/s00590-012-1141-6. - DOI - PubMed
    1. Mei J., Pang L., Jiang Z. The effect of extracorporeal shock wave on osteonecrosis of femoral head: a systematic review and meta-analysis. The Physician and Sportsmedicine . 2021:1–9. doi: 10.1080/00913847.2021.1936685. - DOI - PubMed

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