Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec 6:2021:7906058.
doi: 10.1155/2021/7906058. eCollection 2021.

Imaging Features and Pathological Analysis of 43 Parotid Basal Cell Adenomas

Guiqin Chen  1 , Xiaoyi Wen  2 , X J Chen  1 , Lei Zhang  3 , Z T Lin  4 , Lei Jing  5 , Tiemei Wang  4
Affiliations

Imaging Features and Pathological Analysis of 43 Parotid Basal Cell Adenomas

Guiqin Chen et al. Comput Math Methods Med. .

Abstract

Purpose: To investigate the correlation between sonographic and computed tomography and pathological features of basal cell adenomas (BCAs) of the parotid gland.

Methods: This retrospective study included 41 patients (43 tumors) with BCAs. The tumors were divided into three types based on their location in the parotid gland and their imaging features. The features of the tumors were analyzed.

Results: Imaging manifestations and corresponding pathological results of most BCAs of the parotid glands resembled those of benign parotid gland tumors. Malignant transformation occurred in membranous BCAs and in those with extensive cribriform structures. Type-II and type-III tumors accounted for 82.93% of the total proportion. Thirteen tumors showed cystic degeneration with 30.23%, among which type-III tumors could easily develop cystic degeneration. These cystic areas might correspond to cystic degeneration or focal necrosis. Cystic change was not dependent on the tumor size. The pathological features of the tumors were correlated to their imaging manifestations.

Conclusion: Most BCAs of the parotid glands have imaging manifestations similar to those of benign parotid gland tumors. BCAs with extensive cribriform structures and of the membranous type can show malignant transformation and should be treated with caution in clinical practice.

PubMed Disclaimer

Conflict of interest statement

All authors declare that they do not have any commercial or associative interest that represents a conflict of interest in connection with the work submitted.

Figures

Figure 1
Figure 1
A 20-year-old woman with a membrane-type BCA. (a) Transverse grayscale ultrasonographic image of a 20-year-old woman. There is an ill-defined, regular, hypoechoic mass with heterogeneous internal architecture and without posterior enhancement in the right parotid gland. (b) Intramodular prominent vascularity on Doppler B. (c) Plain computed tomography scan showing an ill-defined regular mass with uneven low density. (d) Hematoxylin and eosin (HE) staining: (membrane type) thickened basement membrane-like substance around a cell mass (×200), scar bar. (e) HE staining: tumor cells invade the capsule (×100).
Figure 2
Figure 2
A 68-year-old woman with a trabecular-type BCA. (a) A 68-year-old woman with a regular, ill-defined, hypoechoic, heterogeneous mass without posterior enhancement in the right parotid gland. (b) Intramodular prominent vascularity on Doppler B. (c) Plain computed tomography scan showing a regular, ill-defined mass with uneven low density. One of the trabecular type with extensive cribriform structures. (d) Computed tomography angiography (CTA): continuous heterogeneous enhancement in the arterial and venous phases. (e) (trabecular) neoplastic basal-like cells are arranged in a cord-like structure (×200). (f) Trabecular mass with extensive cribriform structures (×200); Scar bar. (g) Tumor cells invading the nerves (×100).
Figure 3
Figure 3
A 56-year-old woman of a solid-type BCA. (a, b) Transverse grayscale ultrasonographic image of a 56-year-old woman. An ill-defined, regular, mixed echo mass with heterogeneous internal architecture and with calcification without light posterior enhancement in the right parotid gland. (c) A small amount of blood on Doppler B. (d) Plain computed tomography scan showing a regular, ill-defined, uneven mass with low density and calcification. (e, f) (solid) Tumor cells are arranged in a sheet or island structure, and some are with heteromorphic; extensive cribriform structures are present (×200); Scar bar. (g) Tumors are invading the fat cells (×100).
Figure 4
Figure 4
Immunohistochemistry of BCA: (a) CD 117 (×200); (b) ck 5/6 (×200); (c) ck 8/18 (×200); (d) transformation-related protein 63 (×200); (e) soluble protein-100 (×200); (f) calponin (×200). Scar bar.
See this image and copyright information in PMC

References

    1. Kawata R., Yoshimura K., Lee K., Araki M., Takenaka H., Tsuji M. Basal cell adenoma of the parotid gland: a clinicopathological study of nine cases-basal cell adenoma versus pleomorphic adenoma and Warthin’s tumor. European Archives of Oto-Rhino-Laryngology . 2010;267(5):779–783. doi: 10.1007/s00405-009-1139-9. - DOI - PubMed
    1. Chawla A. J., Tan T. Y., Tan G. J. Basal cell adenomas of the parotid gland: CT scan features. European Journal of Radiology . 2006;58(2):260–265. doi: 10.1016/j.ejrad.2005.12.001. - DOI - PubMed
    1. Barnes L., Eveson J. W., Reichart P. World Health Organization Classification of Tumors: Pathology and Genetics of the Head and Neck Tumours . Lyon, France: IARC Press; 2005.
    1. Lambade P. N., Rajkhokar D., Lambade D. Basal cell adenoma of submandibular salivary gland: a case report and literature review. Journal of Maxillofacial and Oral Surgery . 2015;14(4):999–1003. doi: 10.1007/s12663-014-0709-6. - DOI - PMC - PubMed
    1. Yadav A. B., Narwal A., Devi A., Kumar S., Yadav S. K. Basal cell adenoma of palate, a rare occurrence with review of literature. Journal of Dentistry . 2015;16:p. 291. - PMC - PubMed

MeSH terms

LinkOut - more resources