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Review
. 2021 Nov 29:9:752540.
doi: 10.3389/fcell.2021.752540. eCollection 2021.

The Role of Sphingolipid Metabolism in Bone Remodeling

Tang Qi  1 , Liao Li  1 , Tian Weidong  1
Affiliations
Review

The Role of Sphingolipid Metabolism in Bone Remodeling

Tang Qi et al. Front Cell Dev Biol. .

Abstract

Emerging studies of bioactive lipids have made many exciting discoveries in recent years. Sphingolipids and their metabolites perform a wide variety of cellular functions beyond energy metabolism. Emerging evidence based on genetically manipulated mouse models and molecular biology allows us to obtain new insights into the role sphingolipid played on skeletal remodeling. This review summarizes studies or understandings of the crosstalk between sphingomyelin, ceramide, and sphingosine-1-phosphate (S1P) of sphingolipids family and the cells, especially osteoblasts and osteoclasts of the bone through which bone is remodeled during life constantly. This review also shows agonists and antagonists of S1P as possible therapeutic options and opportunities on bone diseases.

Keywords: S1P; bone remodeling; osteoblast; osteoclast; sphingolipid.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Chemical structures and metabolism of SM, Ceramide, and S1P.
FIGURE 2
FIGURE 2
Sphingolipid pathways.
See this image and copyright information in PMC

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