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. 1986 Jul;6(7):2655-62.
doi: 10.1128/mcb.6.7.2655-2662.1986.

Characterization of murine A-raf, a new oncogene related to the v-raf oncogene

M Huleihel, M Goldsborough, J Cleveland, M Gunnell, T Bonner, U R Rapp

Characterization of murine A-raf, a new oncogene related to the v-raf oncogene

M Huleihel et al. Mol Cell Biol. 1986 Jul.

Abstract

A 1.6-kilobase cDNA (A-raf) has been isolated from a murine spleen cDNA library which encodes part of a protein related to the raf oncogene. Its amino acid sequence has 85% homology to raf in a central portion of 100 amino acids. In contrast to raf, A-raf shows a highly restricted tissue distribution of expression, with highest levels observed in epididymis, followed by intestine. When incorporated into a retrovirus, the resulting gag-A-raf fusion gene causes transformation in vitro and induces tumors in newborn mice. Thus, A-raf represents a new proto-oncogene. Transformation by A-raf is independent of ras gene function, as is the case for raf and mos but not other oncogenes.

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References

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