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. 2022 Apr;36(4):e14563.
doi: 10.1111/ctr.14563. Epub 2022 Jan 6.

A coordinated national UK liver transplant program response, prioritizing waitlist recipients with the highest need, provided excellent outcomes during the first wave of the COVID-19 pandemic

Steven Masson  1 , Rhiannon Taylor  2 , Julie Whitney  2 , Anya Adair  3 , Magdy Attia  4 , Paul Gibbs  5 , Tassos Grammatikopoulos  6 , John Isaac  7 , Aileen Marshall  8 , Darius Mirza  7   9 , Andreas Prachalias  10 , Sarah Watson  11 , Derek Manas  1   2 , John Forsythe  2 , Douglas Thorburn  2   8
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A coordinated national UK liver transplant program response, prioritizing waitlist recipients with the highest need, provided excellent outcomes during the first wave of the COVID-19 pandemic

Steven Masson et al. Clin Transplant. 2022 Apr.

Abstract

Introduction: Healthcare provision has been severely affected by COVID-19, with specific challenges in organ transplantation. Here, we describe the coordinated response to, and outcomes during the first wave, across all UK liver transplant (LT) centers.

Methods: Several policy changes affecting the liver transplant processes were agreed upon. These included donor age restrictions and changes to offering. A "high-urgency" (HU) category was established, prioritizing only those with UKELD > 60, HCC reaching transplant criteria, and others likely to die within 90 days. Outcomes were compared with the same period in 2018 and 2019.

Results: The retrieval rate for deceased donor livers (71% vs. 54%; P < .0001) and conversion from offer to completed transplant (63% vs. 48%; P < .0001) was significantly higher. Pediatric LT activity was maintained; there was a significant reduction in adult (42%) and total (36%) LT. Almost all adult LT were super-urgent (n = 15) or HU (n = 133). We successfully prioritized those with highest illness severity with no reduction in 90-day patient (P = .89) or graft survival (P = .98). There was a small (5% compared with 3%; P = .0015) increase in deaths or removals from the waitlist, mainly amongst HU cohort.

Conclusions: We successfully prioritized LT recipients in highest need, maintaining excellent outcomes, and waitlist mortality was only marginally increased.

Keywords: infection and infectious agents; organ allocation; patient safety; recipient selection; viral; waitlist management.

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References

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