Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022:2410:433-461.
doi: 10.1007/978-1-0716-1884-4_23.

Development of the Antileishmanial Vaccine

Sunil Kumar #  1 , Shubhranshu Zutshi #  1 , Mukesh Kumar Jha  1   2 , Prashant Chauhan  1 , Bhaskar Saha  3   4
Affiliations

Development of the Antileishmanial Vaccine

Sunil Kumar et al. Methods Mol Biol. 2022.

Abstract

Search for an efficacious antileishmanial vaccine has led to clinical trials of numerous vaccine candidates in the past few decades. As no promising candidate has emerged from these studies, novel vaccine modalities and vaccine assessment techniques are still emerging for antileishmanial vaccine development. Briefly, this chapter discusses: (a) history and timeline of antileishmanial vaccine development; (b) techniques utilized for developing whole-parasite and subunit-based antileishmanial vaccine formulations, and (c) immunogenicity and post-challenge protective efficacy assessment of vaccine candidates.

Keywords: Antileishmanial vaccine; Electroporation; Flow cytometry; Immunogenicity; Mass spectrometry; Ni-NTA affinity chromatography; Parasite load; T-helper response.

PubMed Disclaimer

References

    1. Killick-Kendrick R (1990) The life-cycle of Leishmania in the sandfly with special reference to the form infective to the vertebrate host. Ann Parasitol Hum Comp 65:37–42 - PubMed
    1. Guevara P, Pinto-Santíni D, Rojas A, Crisante G, Añez N, Ramirez JL (2001) Green fluorescent protein-tagged Leishmania in phlebotomine sand flies. J Med Entomol 38:39–43 - PubMed
    1. World Health Organization (2020) Leishmaniasis. https://www.who.int/news-room/fact-sheets/detail/leishmaniasis . Accessed 10 Jun 2020
    1. Khamesipour A, Dowlati Y, Asilian A, Hashemi-Fesharki R, Javadi A, Noazin S et al (2005) Leishmanization: use of an old method for evaluation of candidate vaccines against leishmaniasis. Vaccine 23:3642–3648 - PubMed
    1. Handman E (2001) Leishmaniasis: current status of vaccine development. Clin Microbiol Rev 14:229–243 - PubMed - PMC

MeSH terms

LinkOut - more resources