Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Feb 1;205(3):261-263.
doi: 10.1164/rccm.202111-2605ED.

Endotyping Asthma: Profiling the Metabolic Dimension?

Michael J Wilde  1 , Salman Siddiqui  2
Affiliations
Editorial

Endotyping Asthma: Profiling the Metabolic Dimension?

Michael J Wilde et al. Am J Respir Crit Care Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
A collective representation of complementary approaches for the comprehensive capture of the respiratory metabolome and metabolic dysregulation caused by immune-mediated inflammation. Future adoption of multimodal designs, coupling data from tissue scale and liquid and gas phase analyses from across analytical platforms, will provide a more integrated, better annotated understanding of the metabolome, its associated metabolic endotypes, and its potential for therapeutic development in respiratory disease. DESI-MS = desorption electrospray ionization–mass spectrometry; FeNO = fractional exhaled nitric oxide; GC-MS = gas chromatography–mass spectrometry; GCxGC-MS = two-dimensional gas chromatography–mass spectrometry; LC-MS  = liquid chromatography–mass spectrometry; MALDI-MS = matrix-assisted laser desorption/ionization-time of flight–mass spectrometry; MW = molecular weight; Th2 = T-helper cell type 2; VOCs = volatile organic compounds.
See this image and copyright information in PMC

Comment on

References

    1. Anderson GP. Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet . 2008;372:1107–1119. - PubMed
    1. Kelly RS, Mendez KM, Huang M, Hobbs BD, Clish CB, Gerszten R, et al. NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Metabo-endotypes of asthma reveal differences in lung function: discovery and validation in two TOPMed cohorts. Am J Respir Crit Care Med . 2022;205:288–299. - PMC - PubMed
    1. Childhood Asthma Management Program Research Group. The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Control Clin Trials . 1999;20:91–120. - PubMed
    1. Schatz M, Camargo CA., Jr The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization. Ann Allergy Asthma Immunol . 2003;91:553–558. - PubMed
    1. Li L, Zhang H, Holloway JW, Henderson AJ, Ewart S, Relton CL, et al. Pubertal onset with adulthood lung function mediated by height growth in adolescence. ERJ Open Res . 2020;6:00535-2020. - PMC - PubMed