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. 2021 Dec 16;17(12):e1009624.
doi: 10.1371/journal.pcbi.1009624. eCollection 2021 Dec.

A proposed workflow for proactive virus surveillance and prediction of variants for vaccine design

Jordan J Baker  1   2 , Christopher J P Mathy  1 , Julia Schaletzky  3
Affiliations

A proposed workflow for proactive virus surveillance and prediction of variants for vaccine design

Jordan J Baker et al. PLoS Comput Biol. .
No abstract available

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Proposed workflow of consortium to predict and characterize viral VOCs.
Starting with an input of a viral sequence, computational tools and lab-based assays can be implemented to predict VOCs. The results from these approaches, run by experts on the methods, can be fed back into each other to further refine predictions. VOC, variant of concern.
See this image and copyright information in PMC

References

    1. Duffy S. Why are RNA virus mutation rates so damn high? PLoS Biol. 2018;16(8):e3000003. doi: 10.1371/journal.pbio.3000003 - DOI - PMC - PubMed
    1. Park DJ, Dudas G, Wohl S, Goba A, Whitmer SLM, Andersen KG, et al.. Ebola virus epidemiology, transmission, and evolution during seven months in Sierra Leone. Cell. 2015;7(18):1516–26. doi: 10.1016/j.cell.2015.06.007 - DOI - PMC - PubMed
    1. Tsetsarkin KA, Vanlandingham DL, McGee CE, Higgs S. A single mutation in Chikungunya Virus affects vector specificity and epidemic potential. PLoS Pathog. 2007;3(12):e201. doi: 10.1371/journal.ppat.0030201 - DOI - PMC - PubMed
    1. Qu Y, Zhang X, Wang M, Sun L, Jiang Y, Li C, et al.. Antibody Cocktail Exhibits Broad Neutralization against SARS-CoV-2 and SARS-CoV-2 variants. Virol Sin. 2021;36:934–47. doi: 10.1007/s12250-021-00409-4 - DOI - PMC - PubMed
    1. Andreano E, Piccini G, Licastro D, Casalino L, Johnson NV, Paciello I, et al.. SARS-CoV-2 escape from a highly neutralizing COVID-19 convalescent plasma. Proc Natl Acad Sci U S A. 2021;118(36):e2103154118. doi: 10.1073/pnas.2103154118 - DOI - PMC - PubMed

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