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. 2022 Jan 11;327(2):179-181.
doi: 10.1001/jama.2021.22898.

Antibody Response and Variant Cross-Neutralization After SARS-CoV-2 Breakthrough Infection

Timothy A Bates  1 , Savannah K McBride  1 , Bradie Winders  2 , Devin Schoen  2 , Lydie Trautmann  3 , Marcel E Curlin  2 , Fikadu G Tafesse  1
Affiliations

Antibody Response and Variant Cross-Neutralization After SARS-CoV-2 Breakthrough Infection

Timothy A Bates et al. JAMA. .

Abstract

This study of fully vaccinated health care workers examines antibody levels and variant cross-neutralization after COVID-19 breakthrough infection.

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Conflict of interest statement

Conflict of Interest Disclosures: None reported.

Figures

Figure 1.
Figure 1.. SARS-CoV-2 Spike Receptor-Binding Domain (RBD)–Specific Antibody Levels After Vaccination and Breakthrough Infection
Enzyme-linked immunosorbent assay measurement of serum dilution titers with a 50% effective concentration (EC50) of SARS-CoV-2 spike RBD-binding antibodies. The dotted lines indicate the assay limits of detection. Two-tailed P values were determined using the Wilcoxon matched-pairs signed rank test with the Holm-Šídák multiple comparison correction. Box plots were generated using the Tukey method. The large box displays the median and IQR. The error bars indicate 1.5 times the IQR or the furthest outlier, whichever is closer to the median. All individual data points are displayed as filled circles.
Figure 2.
Figure 2.. Live SARS-CoV-2 Variants Neutralization After Vaccination and Breakthrough Infection
Live SARS-CoV-2 neutralization by focus-forming assay. A, The dotted line indicates the assay limit of detection. Two-tailed P values were determined using the Wilcoxon matched-pairs signed rank test with the Holm-Šídák multiple comparison correction. B, Participants with inconclusive sequencing information were excluded from this analysis. Two-tailed P values were determined using the Kruskal-Wallis test with the Dunn multiple comparison correction. Box plots were generated using the Tukey method. The large box displays the median and IQR. The error bars indicate 1.5 times the IQR or the furthest outlier, whichever is closer to the median. All individual data points are displayed as filled circles.
See this image and copyright information in PMC

References

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Publication types

Supplementary concepts