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. 2021 Dec 15;12(12):1127-1130.
doi: 10.1016/j.cels.2021.08.007.

Identifying features of genome evolution to exploit cancer vulnerabilities

Rohan Dandage  1 , Christian R Landry  2
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Identifying features of genome evolution to exploit cancer vulnerabilities

Rohan Dandage et al. Cell Syst. .
Free article

Abstract

Cancer treatment strategies include exploiting genetic vulnerabilities offered by synthetic lethal (SL) interactions between paralogs. In this issue of Cell Systems, De Kegel et al. (2021) apply a machine learning approach to predict robust SL paralogs in the human genome, highlighting genome evolutionary features as key predictors.

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