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Comment
. 2021 Dec 15;109(24):3897-3900.
doi: 10.1016/j.neuron.2021.11.019.

DNA damage rather than type I IFN signaling is the primary mediator of neural dysfunction in Aicardi-Goutières syndrome after RNASEH2 disruption

Martin F Lavin  1 , Abrey J Yeo  2
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Comment

DNA damage rather than type I IFN signaling is the primary mediator of neural dysfunction in Aicardi-Goutières syndrome after RNASEH2 disruption

Martin F Lavin et al. Neuron. .
Free article

Abstract

Mutations in genes that function in nucleic metabolism have been shown to be linked to Aicardi-Goutières syndrome. In this issue of Neuron, Aditi et al. (2021) provide evidence that DNA damage-dependent signaling rather than type I interferon signaling underlies neurodegeneration in this class of neurodevelopmental/neuroinflammatory disease.

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