The new quest in CTLA-4 insufficiency: How to immune modulate effectively?

Affiliations

¹ Division of Allergy/Immunology, Department of Medicine, University of South Florida Morsani College of Medicine, Tampa, Fla; Division of Allergy/Immunology, Department of Pediatrics, University of South Florida Morsani College of Medicine, St Petersburg, Fla.
² Division of Allergy/Immunology, Department of Pediatrics, University of South Florida Morsani College of Medicine, St Petersburg, Fla; Division of Allergy/Immunology, Department of Pediatrics, Johns Hopkins All Children's Hospital, St Petersburg, Fla.
³ Division of Allergy/Immunology, Department of Pediatrics, University of South Florida Morsani College of Medicine, St Petersburg, Fla; Division of Allergy/Immunology, Department of Pediatrics, Johns Hopkins All Children's Hospital, St Petersburg, Fla; Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, Mass. Electronic address: jolanwalter@usf.edu.

Editorial

Emma Westermann-Clark et al. J Allergy Clin Immunol. 2022 Feb.

. 2022 Feb;149(2):543-546.

doi: 10.1016/j.jaci.2021.11.020. Epub 2021 Dec 13.

¹ Division of Allergy/Immunology, Department of Medicine, University of South Florida Morsani College of Medicine, Tampa, Fla; Division of Allergy/Immunology, Department of Pediatrics, University of South Florida Morsani College of Medicine, St Petersburg, Fla.
² Division of Allergy/Immunology, Department of Pediatrics, University of South Florida Morsani College of Medicine, St Petersburg, Fla; Division of Allergy/Immunology, Department of Pediatrics, Johns Hopkins All Children's Hospital, St Petersburg, Fla.
³ Division of Allergy/Immunology, Department of Pediatrics, University of South Florida Morsani College of Medicine, St Petersburg, Fla; Division of Allergy/Immunology, Department of Pediatrics, Johns Hopkins All Children's Hospital, St Petersburg, Fla; Division of Allergy and Immunology, Massachusetts General Hospital for Children, Boston, Mass. Electronic address: jolanwalter@usf.edu.

No abstract available

Keywords: CTLA-4 insufficiency; abatacept; immune dysregulation; transendocytosis; treatment.

Comment on

Therapeutic options for CTLA-4 insufficiency.
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