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Multicenter Study
. 2021 Jan-Dec:28:10732748211066310.
doi: 10.1177/10732748211066310.

Determinants of Second Primary Cancer Type in Survivors of Virus-Related and Non-Virus-Related Cancer Living With HIV in the French Dat'AIDS Cohort

Isabelle Poizot-Martin  1 , Caroline Lions  2 , Clotilde Allavena  3 , Pierre Delobel  4 , Anne Fresard  5 , Sylvie Brégigeon  2 , Teresa Rojas  2 , Cyrille Delpierre  6 , Alain Makinson  7 ; Dat’AIDS study group
Affiliations
Multicenter Study

Determinants of Second Primary Cancer Type in Survivors of Virus-Related and Non-Virus-Related Cancer Living With HIV in the French Dat'AIDS Cohort

Isabelle Poizot-Martin et al. Cancer Control. 2021 Jan-Dec.

Abstract

Objectives: People who survive after primary cancer are at an increased risk for subsequent primary cancers. We aimed to investigate the possible determinants of second primary cancer (SPC) in HIV-positive cancer survivors.

Methods: This was a multicenter retrospective study using longitudinal data from the French Dat'AIDS cohort. Subjects who developed at least 2 primary cancers were selected. Cancer cases were identified using ICD10 codes and distributed in 3 cancer categories: AIDS-defining cancer (ADC), virus-related non-ADC (VR-NADC), and virus-unrelated-NADC (VU-NADC). The possible determinants considered were the first primary cancer category, sex, age, HIV transmission route, duration of HIV infection follow-up, duration of ART exposure, nadir CD4+ T cell count, and hepatitis C and hepatitis B serostatus.

Results: Among the 44642 patients in the Dat'AIDS cohort, 4855 were diagnosed with cancer between 1 December 1983 and 31 December 2015, of whom 444 (9.1%) developed at least 2 primary cancers: 130 ADCs, 85 VR-NADCs, and 229 VU-NADCs. A longer delay between the first primary cancer and the SPC was associated with an increased risk of occurrence of a VR-NADC rather than a secondary ADC. Having had a first primary VU-NADC, an older age, and a longer delay between the HIV diagnosis and the first primary cancer as well as between the first primary cancer and the SPC were associated with an increased risk of VU-NADC rather than ADC.

Conclusion: SPCs are now a major concern in HIV-positive cancer survivors justifying the development of monitoring strategies after a first cancer.

Keywords: AIDS; HIV; associated factors; cancer survivors; secondary primary cancer.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Isabelle Poizot-Martin: consultancies (Gilead Sciences, MSD), travel/accommodation/meeting expenses (Gilead sciences, ViiV healthcare), outside the submitted work.

Clotilde Allavena: honoraria and/or travel grants (Gilead, ViiV Healthcare, Teva, Mylan, MSD and Janssen), outside the submitted work.

Anne Fresard: Travel and congress grants: (Gilead, merck, viiv, Janssen) outside the submitted work.

Alain Makinson: Travel grants (MSD, Mylan; Donations (MSD), outside the submitted work.

Sylvie Brégigeon: congress grants (ViiV, Healthcare), consultancies (ViiV Healthcare, Gilead, Janssen, MSD), outside the submitted work.

Pierre Delobel: Travel grants (MSD, Janssen, ViiV Healthcare) outside the submitted work.Caroline Lions: No conflict of interest.

Teresa Rojas Rojas: No conflict of interest.

Cyrille Delpierre: No conflict of interest.

Figures

Figure 1.
Figure 1.
The distribution of SPCs and subsequent cancer events according to cancers categories ADCs, VR-NADCs, and VU-NADCs. ADCs: AIDS-defining cancer; VR-NADCs: virus-related non-ADCs; VU-NADCs: virus-unrelated non-ADCs.
See this image and copyright information in PMC

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