Synaptic Gain Abnormalities in Schizophrenia and the Potential Relevance for Cognition

Affiliations

¹ Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London, United Kingdom; Wellcome Trust Centre for Human Neuroimaging, University College London, London, United Kingdom. Electronic address: matthew.nour.18@ucl.ac.uk.
² Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London, United Kingdom; Wellcome Trust Centre for Human Neuroimaging, University College London, London, United Kingdom; State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin, Berlin, Germany. Electronic address: r.dolan@ucl.ac.uk.

Comment

Matthew M Nour et al. Biol Psychiatry. 2022.

. 2022 Jan 15;91(2):167-169.

doi: 10.1016/j.biopsych.2021.10.017.

¹ Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London, United Kingdom; Wellcome Trust Centre for Human Neuroimaging, University College London, London, United Kingdom. Electronic address: matthew.nour.18@ucl.ac.uk.
² Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London, United Kingdom; Wellcome Trust Centre for Human Neuroimaging, University College London, London, United Kingdom; State Key Laboratory of Cognitive Neuroscience and Learning, IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China; Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin, Berlin, Germany. Electronic address: r.dolan@ucl.ac.uk.

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Comment on

Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia.
Adams RA, Pinotsis D, Tsirlis K, Unruh L, Mahajan A, Horas AM, Convertino L, Summerfelt A, Sampath H, Du XM, Kochunov P, Ji JL, Repovs G, Murray JD, Friston KJ, Hong LE, Anticevic A. Adams RA, et al. Biol Psychiatry. 2022 Jan 15;91(2):202-215. doi: 10.1016/j.biopsych.2021.07.024. Epub 2021 Aug 10. Biol Psychiatry. 2022. PMID: 34598786 Free PMC article.