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Comment
. 2022 Feb;54(1):116-120.
doi: 10.1016/j.pathol.2021.10.001. Epub 2021 Nov 23.

Weak positive SARS-CoV-2 N2 gene results using the Xpress Xpert assay: the need for an alternate interpretative criteria in a low prevalence setting

Hemalatha Varadhan  1 , Vishal Ahuja  2 , Catherine Pitman  2 , Dominic E Dwyer  2 ; NSW Health Pathology  2
Affiliations
Comment

Weak positive SARS-CoV-2 N2 gene results using the Xpress Xpert assay: the need for an alternate interpretative criteria in a low prevalence setting

Hemalatha Varadhan et al. Pathology. 2022 Feb.
No abstract available

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Figures

Fig. 1
Fig. 1
Suggested flowchart developed to deal with isolated N2 target positive results with CT >40 on the Xpert assay in a low prevalence setting.
See this image and copyright information in PMC

Comment on

References

    1. Cepheid GeneXpert . Cepheid; Sunnyvale, CA: 2020. Xpert Xpress SARS-CoV-2: Instructions for Use.https://www.cepheid.com/Package%20Insert%20Files/Xpert%20Xpress%20SARS-C...
    1. Hueston L., Kok J., Guibone A., et al. The antibody response to SARS-CoV-2 infection. Open Forum Infect Dis. 2020;7 doi: 10.1093/ofid/ofaa387. - DOI - PMC - PubMed
    1. Khoshchehreh M., Wald-Dickler N., Holtom P., Butler-Wu S.M. A needle in the haystack? Assessing the significance of envelope (E) gene-negative, nucleocapsid (N2) gene-positive SARS-CoV-2 detection by the Cepheid Xpert Xpress SARS-COV-2 assay. J Clin Virol. 2020;133:104683. - PMC - PubMed
    1. Falasca F., Sciandra I., Di Carlo D., et al. Detection of SARS-COV N2 gene: very low amounts of viral RNA or false positive? J Clin Virol. 2020;133:104660. - PMC - PubMed
    1. Murphy K. SARS CoV-2 detection from upper and lower respiratory tract specimens: diagnostic and infection control implications. Chest. 2020;158:1804–1805. - PMC - PubMed