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. 2022 May;37(5):1049-1051.
doi: 10.1007/s00467-021-05359-3. Epub 2021 Dec 17.

Non-lupus full-house nephropathy-immune dysregulation as a rare cause of pediatric nephrotic syndrome: Questions

Orsolya Horváth  1   2 , George S Reusz  3 , Veronika Goda  2 , Kata Kelen  1 , István Balogh  4 , Magdolna Kardos  5 , Krisztián Kállay  2 , Áron Cseh  1 , Attila J Szabó  1 , Gergely Kriván  2
Affiliations

Non-lupus full-house nephropathy-immune dysregulation as a rare cause of pediatric nephrotic syndrome: Questions

Orsolya Horváth et al. Pediatr Nephrol. 2022 May.
No abstract available

Keywords: Autoimmunity; Lupus nephritis; Nephrotic syndrome (NS); Primary immunodeficiency (PID); “Full-house” nephropathy (FHN).

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Patient flow chart. NS indicates nephrotic syndrome
Fig. 2
Fig. 2
Histopathologic findings in the non-lupus “full-house” nephropathy case. (1) “Full-house staining” by immunofluorescence: deposits are seen mainly along the glomerular basement membrane and scattered at mesangial sites. (2) Light microscopy showing diffuse mesangial matrix expansion in the glomeruli (arrows, middle, upper panel) and focal endocapillary/mesangial proliferation (asterisks); diffuse thickening of the glomerular basement membrane (arrow 1) with hyaline pseudothrombi (number sign, arrow 2, middle, lower panel). PAS, 600 × . (3) Electron microscopy showing (a) deposits in subepithelial locations and one in subendothelial location with extensive podocyte effacement in the glomerular capillary loop, (b) deposits in mesangial locations, (c) focal mesangial interposition, and (d, e) subepithelial deposits in different stages, with extensive podocyte effacement
See this image and copyright information in PMC

References

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