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Comment
. 2021 Dec 16;81(24):4962-4963.
doi: 10.1016/j.molcel.2021.11.029.

Nuclear pore complexes feel the strain

C Patrick Lusk  1 , Megan C King  2
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Free article
Comment

Nuclear pore complexes feel the strain

C Patrick Lusk et al. Mol Cell. .
Free article

Abstract

A cryo-electron tomography structure of the human nuclear pore complex captured in cellulo by Schuller, Wojtynek et al. reveals that nuclear envelope tension expands the central transport channel and imposes asymmetry in the pore membrane.

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  • The cellular environment shapes the nuclear pore complex architecture.
    Schuller AP, Wojtynek M, Mankus D, Tatli M, Kronenberg-Tenga R, Regmi SG, Dip PV, Lytton-Jean AKR, Brignole EJ, Dasso M, Weis K, Medalia O, Schwartz TU. Schuller AP, et al. Nature. 2021 Oct;598(7882):667-671. doi: 10.1038/s41586-021-03985-3. Epub 2021 Oct 13. Nature. 2021. PMID: 34646014 Free PMC article.

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