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Comment
. 2021 Dec 17;6(1):430.
doi: 10.1038/s41392-021-00852-5.

SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance

Xiantao Zhang  1 , Shijian Wu  1 , Bolin Wu  1 , Qirui Yang  1 , Achun Chen  1 , Yuzhuang Li  1 , Yiwen Zhang  1 , Ting Pan  1   2 , Hui Zhang  3   4 , Xin He  5
Affiliations
Comment

SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance

Xiantao Zhang et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Omicron variant exhibits potent capabilities for immune evasion and viral entrance. a The neutralizing antibodies (nAbs) titers of early convalescent sera against SARS-CoV-2 pseudoviruses (D614G/Beta/Delta/Omicron) were determined and represented as half-maximal inhibitory concentrations (NT50). (n = 27, Adjusted p values were calculated by one-way ANOVA with Tukey’s multiple comparisons test *p < 0.05, ***p < 0.001). b NT50 of each Delta convalescent sera against each pseudotyped virus (n = 18 Adjusted p values were calculated by one-way ANOVA with Tukey’s multiple comparisons test *p < 0.05, ***p < 0.001). c, d The Omicron pseudoviruses were more infectious than other pseudotyped viruses in HEK293T/ACE2 cells. The relative luminescence unit (RLU) of Luc reporter gene expression was standardized as the p24 content of the pseudoviruses (the p24 content of the pseudovirus in the supernatants: D614G = 287 ng/mL, Beta = 306 ng/mL, Delta = 282 ng/ml, Omicron = 289 ng/ml). The background (Bkg) RLU was measured in the wells that received the cells but not the pseudoviruses. e Surface plasmon resonance (SPR) was used to analyze the affinity of Omicron_RBD, D614G_RBD, Beta_RBD, and Delta_RBD bound to ACE2. The KD values were calculated by the software BIAevaluation and shown was a mean of three independent experiments
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References

    1. He, X., Hong, W., Pan, X., Lu, G. & Wei, X. SARS-CoV-2 Omicron variant: characteristics and prevention. MedComm.10.1002/mco2.110 (2021). Epub ahead. - PMC - PubMed
    1. World Health Organization. Classification of Omicron (B.1.1.529): SARS-CoV-2 variant of concern. https://www.who.int/news/item/26-11-2021-classification-of-omicron-(b.1.... (2021).
    1. The Global Initiative on Sharing All Influenza Data (GISAID). Tracking of variants. (2021).
    1. Pan T, et al. Significantly reduced abilities to cross-neutralize SARS-CoV-2 variants by sera from convalescent COVID-19 patients infected by Delta or early strains. Cell Mol. Immunol. 2021;18:2560–2562. doi: 10.1038/s41423-021-00776-8. - DOI - PMC - PubMed
    1. Harvey WT, et al. SARS-CoV-2 variants, spike mutations and immune escape. Nat. Rev. Microbiol. 2021;19:409–424. doi: 10.1038/s41579-021-00573-0. - DOI - PMC - PubMed