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Comment
. 2021 Dec 17;6(1):430.
doi: 10.1038/s41392-021-00852-5.

SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance

Xiantao Zhang  1 , Shijian Wu  1 , Bolin Wu  1 , Qirui Yang  1 , Achun Chen  1 , Yuzhuang Li  1 , Yiwen Zhang  1 , Ting Pan  1   2 , Hui Zhang  3   4 , Xin He  5
Affiliations
Comment

SARS-CoV-2 Omicron strain exhibits potent capabilities for immune evasion and viral entrance

Xiantao Zhang et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Omicron variant exhibits potent capabilities for immune evasion and viral entrance. a The neutralizing antibodies (nAbs) titers of early convalescent sera against SARS-CoV-2 pseudoviruses (D614G/Beta/Delta/Omicron) were determined and represented as half-maximal inhibitory concentrations (NT50). (n = 27, Adjusted p values were calculated by one-way ANOVA with Tukey’s multiple comparisons test *p < 0.05, ***p < 0.001). b NT50 of each Delta convalescent sera against each pseudotyped virus (n = 18 Adjusted p values were calculated by one-way ANOVA with Tukey’s multiple comparisons test *p < 0.05, ***p < 0.001). c, d The Omicron pseudoviruses were more infectious than other pseudotyped viruses in HEK293T/ACE2 cells. The relative luminescence unit (RLU) of Luc reporter gene expression was standardized as the p24 content of the pseudoviruses (the p24 content of the pseudovirus in the supernatants: D614G = 287 ng/mL, Beta = 306 ng/mL, Delta = 282 ng/ml, Omicron = 289 ng/ml). The background (Bkg) RLU was measured in the wells that received the cells but not the pseudoviruses. e Surface plasmon resonance (SPR) was used to analyze the affinity of Omicron_RBD, D614G_RBD, Beta_RBD, and Delta_RBD bound to ACE2. The KD values were calculated by the software BIAevaluation and shown was a mean of three independent experiments
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