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. 2021 Dec 18;12(12):CD010583.
doi: 10.1002/14651858.CD010583.pub5.

Prophylactic abdominal drainage for pancreatic surgery

Sirong He  1 , Jie Xia  2 , Wei Zhang  3 , Mingliang Lai  4 , Nansheng Cheng  5 , Zuojin Liu  1 , Yao Cheng  1
Affiliations

Prophylactic abdominal drainage for pancreatic surgery

Sirong He et al. Cochrane Database Syst Rev. .

Update in

Abstract

Background: The use of surgical drains is a very common practice after pancreatic surgery. The role of prophylactic abdominal drainage to reduce postoperative complications after pancreatic surgery is controversial. This is the third update of a previously published Cochrane Review to address the uncertain benifits of prophylactic abdominal drainage in pancreatic surgery.

Objectives: To assess the benefits and harms of routine abdominal drainage after pancreatic surgery, compare the effects of different types of surgical drains, and evaluate the optimal time for drain removal.

Search methods: In this updated review, we re-searched CENTRAL, MEDLINE, Embase, Science Citation Index Expanded, and the Chinese Biomedical Literature Database (CBM) on 08 February 2021.

Selection criteria: We included all randomised controlled trials (RCTs) that compared abdominal drainage versus no drainage in people undergoing pancreatic surgery. We also included RCTs that compared different types of drains and different schedules for drain removal in people undergoing pancreatic surgery.

Data collection and analysis: Two review authors independently identified the studies for inclusion, collected the data, and assessed the risk of bias. We conducted the meta-analyses using Review Manager 5. We calculated the risk ratio (RR) for dichotomous outcomes and the mean difference (MD) or standardized mean difference (SMD) for continuous outcomes with 95% confidence intervals (CI). For all analyses, we used the random-effects model. We used GRADE to assess the certainty of the evidence for important outcomes.

Main results: We identified a total of nine RCTs with 1892 participants. Drain use versus no drain use We included four RCTs with 1110 participants, randomised to the drainage group (N = 560) and the no drainage group (N = 550) after pancreatic surgery. Low-certainty evidence suggests that drain use may reduce 90-day mortality (RR 0.23, 95% CI 0.06 to 0.90; two studies, 478 participants). Compared with no drain use, low-certainty evidence suggests that drain use may result in little to no difference in 30-day mortality (RR 0.78, 95% CI 0.31 to 1.99; four studies, 1055 participants), wound infection rate (RR 0.98, 95% CI 0.68 to 1.41; four studies, 1055 participants), length of hospital stay (MD -0.14 days, 95% CI -0.79 to 0.51; three studies, 876 participants), the need for additional open procedures for postoperative complications (RR 1.33, 95% CI 0.79 to 2.23; four studies, 1055 participants), and quality of life (105 points versus 104 points; measured with the pancreas-specific quality of life questionnaire (scale 0 to 144, higher values indicating a better quality of life); one study, 399 participants). There was one drain-related complication in the drainage group (0.2%). Moderate-certainty evidence suggests that drain use probably resulted in little to no difference in morbidity (RR 1.03, 95% CI 0.94 to 1.13; four studies, 1055 participants). The evidence was very uncertain about the effect of drain use on intra-abdominal infection rate (RR 0.97, 95% CI 0.52 to 1.80; four studies, 1055 participants; very low-certainty evidence), and the need for additional radiological interventions for postoperative complications (RR 0.87, 95% CI 0.40 to 1.87; three studies, 660 participants; very low-certainty evidence). Active versus passive drain We included two RCTs involving 383 participants, randomised to the active drain group (N = 194) and the passive drain group (N = 189) after pancreatic surgery. Compared with a passive drain, the evidence was very uncertain about the effect of an active drain on 30-day mortality (RR 1.23, 95% CI 0.30 to 5.06; two studies, 382 participants; very low-certainty evidence), intra-abdominal infection rate (RR 0.87, 95% CI 0.21 to 3.66; two studies, 321 participants; very low-certainty evidence), wound infection rate (RR 0.92, 95% CI 0.44 to 1.90; two studies, 321 participants; very low-certainty evidence), morbidity (RR 0.97, 95% CI 0.53 to 1.77; two studies, 382 participants; very low-certainty evidence), length of hospital stay (MD -0.79 days, 95% CI -2.63 to 1.04; two studies, 321 participants; very low-certainty evidence), and the need for additional open procedures for postoperative complications (RR 0.44, 95% CI 0.11 to 1.83; two studies, 321 participants; very low-certainty evidence). There was no drain-related complication in either group. Early versus late drain removal We included three RCTs involving 399 participants with a low risk of postoperative pancreatic fistula, randomised to the early drain removal group (N = 200) and the late drain removal group (N = 199) after pancreatic surgery. Compared to late drain removal, the evidence was very uncertain about the effect of early drain removal on 30-day mortality (RR 0.99, 95% CI 0.06 to 15.45; three studies, 399 participants; very low-certainty evidence), wound infection rate (RR 1.32, 95% CI 0.45 to 3.85; two studies, 285 participants; very low-certainty evidence), hospital costs (SMD -0.22, 95% CI -0.59 to 0.14; two studies, 258 participants; very low-certainty evidence), the need for additional open procedures for postoperative complications (RR 0.77, 95% CI 0.28 to 2.10; three studies, 399 participants; very low-certainty evidence), and the need for additional radiological procedures for postoperative complications (RR 1.00, 95% CI 0.21 to 4.79; one study, 144 participants; very low-certainty evidence). We found that early drain removal may reduce intra-abdominal infection rate (RR 0.44, 95% CI 0.22 to 0.89; two studies, 285 participants; very low-certainty evidence), morbidity (RR 0.49, 95% CI 0.30 to 0.81; two studies, 258 participants; very low-certainty evidence), and length of hospital stay (MD -2.20 days, 95% CI -3.52 to -0.87; three studies, 399 participants; very low-certainty evidence), but the evidence was very uncertain. None of the studies reported on drain-related complications.

Authors' conclusions: Compared with no drain use, it is unclear whether routine drain use has any effect on mortality at 30 days or postoperative complications after pancreatic surgery. Compared with no drain use, low-certainty evidence suggests that routine drain use may reduce mortality at 90 days. Compared with a passive drain, the evidence is very uncertain about the effect of an active drain on mortality at 30 days or postoperative complications. Compared with late drain removal, early drain removal may reduce intra-abdominal infection rate, morbidity, and length of hospital stay for people with low risk of postoperative pancreatic fistula, but the evidence is very uncertain.

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Conflict of interest statement

SH: None known

JX: None known

WZ: None known

ML: None known

NC: None known

ZL: None known

YC: None known

Figures

1
1
Study flow diagram: 2021 review update
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study
1.1
1.1. Analysis
Comparison 1: Drain use versus no drain use, Outcome 1: Mortality (30 days)
1.2
1.2. Analysis
Comparison 1: Drain use versus no drain use, Outcome 2: Mortality (90 days)
1.3
1.3. Analysis
Comparison 1: Drain use versus no drain use, Outcome 3: Intra‐abdominal infection
1.4
1.4. Analysis
Comparison 1: Drain use versus no drain use, Outcome 4: Wound infection
1.5
1.5. Analysis
Comparison 1: Drain use versus no drain use, Outcome 5: Morbidity
1.6
1.6. Analysis
Comparison 1: Drain use versus no drain use, Outcome 6: Length of hospital stay (days)
1.8
1.8. Analysis
Comparison 1: Drain use versus no drain use, Outcome 8: Additional open procedures for postoperative complications
1.9
1.9. Analysis
Comparison 1: Drain use versus no drain use, Outcome 9: Additional radiological interventions for postoperative complications
2.1
2.1. Analysis
Comparison 2: Active drain versus passive drain, Outcome 1: Mortality (30 days)
2.2
2.2. Analysis
Comparison 2: Active drain versus passive drain, Outcome 2: Intra‐abdominal infection
2.3
2.3. Analysis
Comparison 2: Active drain versus passive drain, Outcome 3: Wound infection
2.4
2.4. Analysis
Comparison 2: Active drain versus passive drain, Outcome 4: Morbidity
2.5
2.5. Analysis
Comparison 2: Active drain versus passive drain, Outcome 5: Length of hospital stay (days)
2.6
2.6. Analysis
Comparison 2: Active drain versus passive drain, Outcome 6: Additional open procedures for postoperative complications
3.1
3.1. Analysis
Comparison 3: Early versus late drain removal, Outcome 1: Mortality (30 days)
3.2
3.2. Analysis
Comparison 3: Early versus late drain removal, Outcome 2: Intra‐abdominal infection
3.3
3.3. Analysis
Comparison 3: Early versus late drain removal, Outcome 3: Wound infection
3.4
3.4. Analysis
Comparison 3: Early versus late drain removal, Outcome 4: Morbidity
3.5
3.5. Analysis
Comparison 3: Early versus late drain removal, Outcome 5: Length of hospital stay (days)
3.6
3.6. Analysis
Comparison 3: Early versus late drain removal, Outcome 6: Hospital costs
3.7
3.7. Analysis
Comparison 3: Early versus late drain removal, Outcome 7: Additional open procedures for postoperative complications
3.8
3.8. Analysis
Comparison 3: Early versus late drain removal, Outcome 8: Additional radiological interventions for postoperative complications
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