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. 2022 Apr;77(4):1297-1299.
doi: 10.1111/all.15198. Epub 2021 Dec 26.

Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize non-steroidal anti-inflammatory drug exacerbated respiratory disease

Anand Kumar Andiappan  1 , Mohammad Asad  2 , Celine Chua  3 , Esha Sehanobish  2 , Zhen Ren  4 , Xue Ying Chan  1 , Josephine Lum  1 , Nicholas Ang  1 , Kaibo Duan  1 , Adam Gersten  2 , Waleed M Abuzeid  5 , Nadeem Akbar  2 , Marc Gibber  2 , Shanshan Howland  1 , Bernett Lee  1 , Olaf Rotzschke  1 , Steven A Porcelli  2 , Elina Jerschow  2
Affiliations

Neutrophilic inflammation and epithelial barrier disruption in nasal polyps characterize non-steroidal anti-inflammatory drug exacerbated respiratory disease

Anand Kumar Andiappan et al. Allergy. 2022 Apr.
No abstract available

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Conflict of interest statement

Conflict of interest:

For Elina Jerschow:

Advisory Board - GlaxoSmithKline, Sanofi-Regeneron, Novartis/Genentech.

Consultant –GlaxoSmithKline. None of these are relevant to this work.

Other authors declare no conflict of interest

Figures

Figure 1:
Figure 1:. Characteristics of the study cohort stratified by N-ERD status
(A) Lund-Mackay (LM) score. (B) Polyp tissue neutrophil counts per high-power field (hpf). (C) Polyp tissue eosinophil counts per high-power field (hpf). A cutoff score was set at 80 eosinophils per hpf. (D) Heat map showing subset of DEGs selected by more stringent criteria of FDR p-value < 0.05. All 10 of the genes listed were significantly downregulated in N-ERD versus non-N-ERD. Gene expression shown as an average of the samples log2RPKM (reads per kilobase of transcript, per million mapped reads) values in each of the two groups. Red colors denote higher expression while light-red to blue colors indicate lower expression levels of the genes. Ingenuity Pathway Analysis (IPA) of differentially expressed genes (DEGs) highlighting relevant biological pathways under (E) Diseases and Disorders, (F) Molecular and Cell Function and (G) Physiological system based on a cut off of nominally significant P-value < 0.05.
See this image and copyright information in PMC

References

    1. Khan A, Vandeplas G, Huynh TMT, Joish VN, Mannent L, Tomassen P, et al. The Global Allergy and Asthma European Network (GALEN rhinosinusitis cohort: a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps. Rhinology. 2019;57(1):32–42. - PubMed
    1. Kowalski ML, Agache I, Bavbek S, Bakirtas A, Blanca M, Bochenek G, et al. Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper. Allergy. 2019;74(1):28–39. - PubMed
    1. Cornet M, Kristina K, Bas R, Koos Z, Wytske F. Expression profiling of nasal polyp epithelial cells identifies two distinct phenotypes and suggests a role for neurogenic inflammation. Clin Trans Allergy. 2015. Dec;5(4):1-.
    1. Callejas-Díaz B, Fernandez G, Fuentes M, Martínez-Antón A, Alobid I, Roca-Ferrer J et al.. Integrated mRNA and microRNA transcriptome profiling during differentiation of human nasal polyp epithelium reveals an altered ciliogenesis. Allergy 2020;75:2548–2561. - PubMed
    1. Stevens WW, Peters AT, Tan BK, Klingler AI, Poposki JA, Hulse KE, et al. Associations Between Inflammatory Endotypes and Clinical Presentations in Chronic Rhinosinusitis. J Allergy Clin Immunol Pract. 2019;7(8):2812–20 e3. - PMC - PubMed

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