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. 2021 Dec 13;21(1):711.
doi: 10.1186/s12877-021-02602-2.

Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality

Rosanne Freak-Poli  1 , Joanne Ryan  2 , Johannes T Neumann  2   3   4 , Andrew Tonkin  2 , Christopher M Reid  2   5 , Robyn L Woods  2 , Mark Nelson  2   6 , Nigel Stocks  7 , Michael Berk  2   8   9 , John J McNeil  2 , Carlene Britt  2 , Alice J Owen  10
Affiliations

Social isolation, social support and loneliness as predictors of cardiovascular disease incidence and mortality

Rosanne Freak-Poli et al. BMC Geriatr. .

Abstract

Background: Poor social health is associated with increased risk of cardiovascular disease (CVD). Recent research suggests that different social health domains should be considered separately as the implications for health and possible interventions may differ.

Aim: To assess social isolation, low social support and loneliness as predictors of CVD.

Methods: Secondary analysis of 11,486 community-dwelling, Australians, aged 70 years and over, free of CVD, dementia, or significant physical disability, from the ASPirin in Reducing Events in the Elderly (ASPREE) trial. Social isolation, social support (Revised Lubben Social Network Scale), and loneliness were assessed as predictors of CVD using Cox proportional-hazard regression. CVD events included fatal CVD, heart failure hospitalization, myocardial infarction and stroke. Analyses were adjusted for established CVD risk factors.

Results: Individuals with poor social health were 42 % more likely to develop CVD (p = 0.01) and twice as likely to die from CVD (p = 0.02) over a median 4.5 years follow-up. Interaction effects indicated that poorer social health more strongly predicted CVD in smokers (HR 4.83, p = 0.001, p-interaction = 0.01), major city dwellers (HR 1.94, p < 0.001, p-interaction=0.03), and younger older adults (70-75 years; HR 2.12, p < 0.001, p-interaction = 0.01). Social isolation (HR 1.66, p = 0.04) and low social support (HR 2.05, p = 0.002), but not loneliness (HR 1.4, p = 0.1), predicted incident CVD. All measures of poor social health predicted ischemic stroke (HR 1.73 to 3.16).

Conclusions: Among healthy older adults, social isolation and low social support may be more important than loneliness as cardiovascular risk factors. Social health domains should be considered in future CVD risk prediction models.

Keywords: Aging; Cardiovascular Diseases; Geriatrics; Interpersonal Relations; Loneliness; Social Isolation; Social Support.

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Conflict of interest statement

None declared. The data collection, analysis and interpretation of data; the writing of the manuscript; and the decision to submit the manuscript for publication were solely at the discretion of the researchers, independent of the funders.

Figures

Fig. 1
Fig. 1
Cumulative incidence and mortality of cardiovascular disease by baseline social health status, n = 11,486
Fig. 2
Fig. 2
Subgroup stratification: Social health as a predictor of incident cardiovascular disease over five years for older adults recruited between 2010 and 2014 in Australia, n = 11,486
See this image and copyright information in PMC

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