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. 2021 Dec 18;21(1):419.
doi: 10.1186/s12905-021-01571-3.

Global, regional, and national burden of cervical cancer for 195 countries and territories, 2007-2017: findings from the Global Burden of Disease Study 2017

Miaomiao Zhao  1 , Qunhong Wu  2 , Yanhua Hao  2 , Jingcen Hu  3   4 , Yuexia Gao  1 , Shan Zhou  5 , Liyuan Han  6   7
Affiliations

Global, regional, and national burden of cervical cancer for 195 countries and territories, 2007-2017: findings from the Global Burden of Disease Study 2017

Miaomiao Zhao et al. BMC Womens Health. .

Abstract

Background: Cervical cancer is one of the most common cancers among women worldwide. The formulation or evaluation on prevention strategies all require an accurate understanding of the burden for cervical cancer burden. We aimed to report the up-to-date estimates of cervical cancer burden at global, regional, and national levels.

Methods: Data were extracted from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 study. The counts, age-standardized rates, and percentage changes of incidence, disability-adjusted life-years (DALYs), and death attributed to cervical cancer at the global, regional, and national levels in all 195 countries and territories from 21 regions during 2007 to 2017 by age and by Socio-demographic Index (SDI) were measured. All estimates were reported with 95% uncertainty intervals (UIs).

Results: In 2017, 601,186 (95% UI 554,455 to 625,402) incident cases of cervical cancer were reported worldwide, which caused 8,061,667 (7,527,014 to 8,401,647) DALYs and 259,671 (241,128 to 269,214) deaths. The age-standardized rates for incidence, DALYs and death decreased by - 2.8% (- 7.8% to 0.6%), - 7.1% [- 11.8% to - 3.9%] and - 6.9% [- 11.5% to - 3.7%] from 2007 to 2017, respectively. The highest age-standardized incidence, DALYs and death rates in 2017 were observed in the low SDI quintile, Oceania, Central and Eastern Sub-Saharan Africa. During 2007 to 2017, only East Asia showed increase in these rates despite not significant. At the national level, the highest age-standardized rates for incidence, DALYs, and death in 2017 were observed in Kiribati, Somalia, Eritrea, and Central African Republic; and Georgia showed the largest increases in all these rates during 2007 to 2017.

Conclusion: Although the age-standardized rates for incidence, DALYs, and death of cervical cancer have decreased in most parts of the world from 2007 to 2017, cervical cancer remains a major public health concern in view of the absolute number of cervical cancer cases, DALYs, and deaths increased during this period. The challenge is more prone to in the low SDI quintile, Oceania, Central and Eastern Sub-Saharan Africa, East Asia, and some countries, suggesting an urgent to promote human papillomavirus vaccination in these regions.

Keywords: Cervical cancer; Death; Disability-adjusted life-years; Global Burden of Disease; Human papillomavirus; Incidence.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Age-standardized rates for incidence (A), DALYs (C), and death (E) of cervical cancer in 2017, and percentage change of age-standardized rates for incidence (B), DALYs (D), and death (F) of cervical cancer between 2007 and 2017, globally, by SDI quintile and by 21 GDB regions. DALYs disability-adjusted life-years, SDI socio-demographic index
Fig. 2
Fig. 2
Age-standardize rates for incidence (A), DALYs (B) and death (C) of cervical cancer across 195 countries and territories, 2017. This figure was drawn using the extracted data by the authors. DALYs disability-adjusted life-years
Fig. 3
Fig. 3
Age-distribution for incident, DALYs, and death cases of cervical cancer by 21GBD regions, 2007 and 2017. A Incident cases of cervical cancer in 2007. B Incident cases of cervical cancer in 2017. C DALYs cases s of cervical cancer in 2007. D DALYs cases of cervical cancer in 2017. E Death cases of cervical cancer in 2007. F Death cases of cervical cancer in 2017. DALYs disability-adjusted life-years, SDI socio-demographic index
Fig. 4
Fig. 4
The trend in age-standardized incidence (A), DALYs (B), and death (C) rates of cervical cancer in 21 GBD regions by SDI, 1990–2017. For each region, points from left to right depict estimates from each year from 1990 to 2017. The black line represents the average expected relationship between SDI and burden estimates rates for T2DM based on values from each geographical region over the 1990–2017 estimation period. DALYs disability-adjusted life-years, SDI socio-demographic index
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