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Multicenter Study
. 2022 Apr 1;36(5):665-673.
doi: 10.1097/QAD.0000000000003152.

Incidence of lung and human papilloma virus-associated malignancies in HIV-infected patients

Hélène Chaussade  1 , Fabien Le Marec  2 , Gaëlle Coureau  3 , Olivier Leleux  2 , Didier Neau  4 , Estibaliz Lazaro  5 , Brice Amadeo  3 , Pierre Duffau  1 , Hélène Ferrand  6 , Carine Courtault  7 , Anne-Sophie Foucan  3 , Linda Wittkop  2 , Fabrice Bonnet  1   2
Affiliations
Multicenter Study

Incidence of lung and human papilloma virus-associated malignancies in HIV-infected patients

Hélène Chaussade et al. AIDS. .

Abstract

Objective: Cancers represent one of the leading cause of mortality/morbidity in patients with HIV (PWH) in industrialized countries. The objective of our study was to compare incidence of lung and human papilloma virus (HPV)-related cancers among PWH with general population over the 2010-2017 period.

Design: Prospective and multicenter cohort study.

Methods: The study included patients with lung and HPV-related cancers from the ANRS CO3 Aquitaine cohort (PWH) and the general population-based cancer registry in Gironde area. We calculated incidence rates for 100 000 person-years and incidence rate ratios (IRR).

Results: Among the 3572 PWH, 70 cancers were diagnosed in 68 patients including 35 lung and 35 HPV-related cancers (18 oropharyngeal, 11 anal, 6 cervix). Incidence rates of lung and HPV-related-cancers were 311.1 in PWH and 209.8 in general population for 100 000 person-years, respectively. IRR were significantly increased in PWH for lung 1.8 [1.4-2.2] and HPV-related cancer 1.3 [1.0-1.6] and particularly high for patients between 40 and 49 years old [IRR 4.4 (2.3-8.4) for lung cancer and 3.7 (2.1-6.5) for HPV-related cancer].

Conclusion: We emphasized the persistent high risk of lung and HPV-related cancer despite advent of antiretroviral therapies, particularly in the age strata of 40-49 years. Screening procedures should take into account this finding.

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