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. 2022 Jan 6;51(1):afab231.
doi: 10.1093/ageing/afab231.

Diabetes duration and the risk of dementia: a cohort study based on German health claims data

Constantin Reinke  1 , Nikolaus Buchmann  2 , Anne Fink  3 , Christina Tegeler  2   4 , Ilja Demuth  2   5 , Gabriele Doblhammer  1   3
Affiliations

Diabetes duration and the risk of dementia: a cohort study based on German health claims data

Constantin Reinke et al. Age Ageing. .

Abstract

Objective: Diabetes is a risk factor for dementia but little is known about the impact of diabetes duration on the risk of dementia. We investigated the effect of type 2 diabetes duration on the risk of dementia.

Design: Prospective cohort study using health claims data representative for the older German population. The data contain information about diagnoses and medical prescriptions from the in- and outpatient sector.

Methods: We performed piecewise exponential models with a linear and a quadratic term for time since first type 2 diabetes diagnosis to predict the dementia risk in a sample of 13,761 subjects (2,558 dementia cases) older than 65 years. We controlled for severity of diabetes using the Adopted Diabetes Complications Severity Index.

Results: We found a U-shaped dementia risk over time. After type 2 diabetes diagnosis the dementia risk decreased (26% after 1 year) and reached a minimum at 4.75 years, followed by an increase through the end of follow-up. The pattern was consistent over different treatment groups, with the strongest U-shape for insulin treatment and for those with diabetes complications at the time of diabetes diagnosis.

Conclusions: We identified a non-linear association of type 2 diabetes duration and the risk of dementia. Physicians should closely monitor cognitive function in diabetic patients beyond the first few years after diagnosis, because the later increase in dementia occurred in all treatment groups.

Keywords: Type 2 diabetes; dementia; health claims data; older people; risk factors.

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Figures

Figure 1
Figure 1
Predicted risk of dementia over time since incident T2D diagnosis. CI = Confidence intervals. Source: AOK data 2004–2015, authors’ calculations.
Figure 2
Figure 2
Predicted risk of dementia over time since incident T2D diagnosis for treatment groups. CI = Confidence intervals. Note different y-axis scales. Source: AOK data 2004–2015, authors’ calculations.
Figure 3
Figure 3
Predicted risk of dementia over time since T2D by diabetes severity at T2D incidence. Source: AOK data 2004–2015, authors’ calculations.
See this image and copyright information in PMC

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