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. 2021 Dec 19;7(1):117.
doi: 10.1186/s40729-021-00393-0.

Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review

Sarah Al-Maawi  1 , Kathrin Becker  2 , Frank Schwarz  3 , Robert Sader  1 , Shahram Ghanaati  4
Affiliations

Efficacy of platelet-rich fibrin in promoting the healing of extraction sockets: a systematic review

Sarah Al-Maawi et al. Int J Implant Dent. .

Abstract

Purpose: To address the focused question: in patients with freshly extracted teeth, what is the efficacy of platelet-rich fibrin (PRF) in the prevention of pain and the regeneration of soft tissue and bone compared to the respective control without PRF treatment?

Methods: After an electronic data search in PubMed database, the Web of Knowledge of Thomson Reuters and hand search in the relevant journals, a total of 20 randomized and/or controlled studies were included.

Results: 66.6% of the studies showed that PRF significantly reduced the postoperative pain, especially in the first 1-3 days after tooth extraction. Soft tissue healing was significantly improved in the group of PRF compared to the spontaneous wound healing after 1 week (75% of the evaluated studies). Dimensional bone loss was significantly lower in the PRF group compared to the spontaneous wound healing after 8-15 weeks but not after 6 months. Socket fill was in 85% of the studies significantly higher in the PRF group compared to the spontaneous wound healing.

Conclusions: Based on the analyzed studies, PRF is most effective in the early healing period of 2-3 months after tooth extraction. A longer healing period may not provide any benefits. The currently available data do not allow any statement regarding the long-term implant success in sockets treated with PRF or its combination with biomaterials. Due to the heterogeneity of the evaluated data no meta-analysis was performed.

Keywords: PRF; Pain management; Platelet-rich fibrin; Ridge preservation; Socket healing; Socket preservation; Soft tissue healing.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

Fig. 1
Fig. 1
Flowchart describing the research strategy and study selection (modified according to the PRISMA 2020 statement: an updated guideline for reporting systematic reviews [36])
Fig. 2
Fig. 2
Bias risk assessment of RCTs according to the Cochrane collaborations tool
See this image and copyright information in PMC

Comment in

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