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Review
. 2022 May:81:98-110.
doi: 10.1016/j.bpobgyn.2021.09.011. Epub 2021 Nov 16.

Premature ovarian insufficiency

Sinéad M McGlacken-Byrne  1 , Gerard S Conway  2
Affiliations
Review

Premature ovarian insufficiency

Sinéad M McGlacken-Byrne et al. Best Pract Res Clin Obstet Gynaecol. 2022 May.

Abstract

The natural lifespan of the ovary is occasionally interrupted by pathological processes; some are known, but many are unknown. Premature ovarian insufficiency (POI) can be a devastating diagnosis for an adolescent or for someone who has yet to start a family. Common causes of POI include genetic and chromosomal defects, autoimmune damage, and cancer treatments. Knowledge of the pathogenesis of this condition and an awareness of contemporary hormone replacement and fertility options are required to design a multidisciplinary therapeutic approach comprising reproductive medicine, endocrinology, clinical psychology, and assisted fertility expertise.

Keywords: Fertility; HRT; Meiosis; Oestradiol; Progesterone.

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Conflict of interest statement

Declaration of competing interest The authors have no conflict of interest.

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