Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jan 1;36(Suppl 1):S21-S25.
doi: 10.1097/BOT.0000000000002297.

Long-Term Consequences of Major Extremity Trauma: A Pilot Study

Affiliations

Long-Term Consequences of Major Extremity Trauma: A Pilot Study

Renan C Castillo et al. J Orthop Trauma. .

Abstract

Limited data are available on the longer-term physical and psychosocial consequences after major extremity trauma apart from literature on the consequences after major limb amputation. The existing literature suggests that although variations in outcome exist, a significant proportion of service members and civilians sustaining major limb trauma will have less than optimal outcomes or health and rehabilitation needs over their life course. The proposed pilot study will address this gap in current research by locating and consenting METRC participants with the period of 5-7 years postinjury, identifying potential participation barriers and appropriate use of incentives, and conducting the follow-up examination at several data collection sites. The resulting data will inform the primary objective of refining and developing specific hypotheses to determine the design, scope, and feasibility of the main long-term consequences of major extremity trauma. Three METRC enrollment centers will contact past participants to achieve the goal of completing an interview, select patient-reported outcomes, perform a medical record review, and conduct an in-person clinic visit that will consist of a physical examination, blood draw, and x-ray of the study injury area. If successful, it will be possible to design studies to further examine these effects and develop future therapeutic interventions.

PubMed Disclaimer

Conflict of interest statement

M.J. Weaver receives intellectual property royalties from OsteoCentric. The details of the contracts are disclosed through AAOS and have no direct or apparent relationship with the current article. The remaining authors report no conflict of interest.

References

    1. Penn-Barwell JG. Outcomes in lower limb amputation following trauma: a systematic review and meta-analysis. Injury. 2011;42:1474–1479.
    1. Amtmann D, Morgan SJ, Kim J, et al. Health-related profiles of people with lower limb loss. Arch Phys Med Rehabil. 2015;96:1474–1483.
    1. Fitzgibbons P, Medvedev G. Functional and clinical outcomes of upper extremity amputation. J Am Acad Orthop Surg. 2015;23:751–760.
    1. MacKenzie EJ, Bosse MJ, Pollak AN, et al. Long-term persistence of disability following severe lower-limb trauma. Results of a seven-year follow-up. J Bone Joint Surg Am. 2005;87:1801–1809.
    1. MacKenzie EJ, Bosse MJ, Kellam JF, et al. Early predictors of long-term work disability after major limb trauma. J Trauma. 2006;61:688–694.

LinkOut - more resources