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. 2021 Dec 2:28:112-116.
doi: 10.1016/j.jor.2021.11.018. eCollection 2021 Nov-Dec.

Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis

Henry T Shu  1 , Jacob D Mikula  1 , Andrew T Yu  2 , Babar Shafiq  1
Affiliations

Tranexamic acid use in pelvic and/or acetabular fracture surgery: A systematic review and meta-analysis

Henry T Shu et al. J Orthop. .

Abstract

Purpose: The purpose of this study is to determine whether tranexamic acid (TXA) use was associated with lower rates of blood transfusion in patients undergoing pelvic and/or acetabular fracture surgery.

Methods: Four studies were included, 3 of which were included in the pooled data analysis for a total of 308 patients.

Results: The transfusion rate was significantly lower in the TXA group (44%) compared with the non-TXA group (57%) (P = 0.02).

Conclusion: TXA use was associated with a significantly lower transfusion rate in patients who underwent pelvic and/or acetabular fracture surgery.

Level of evidence: Level 3. Systematic review of retrospective cohort studies and prospective randomized controlled trials.

Keywords: Acetabulum fracture; Antifibrinolysis; Orthopaedic trauma; Pelvic fracture; Tranexamic acid.

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Conflict of interest statement

Babar Shafiq, MD, MSPT is a paid consultant for DePuy Synthes and Bone Foam. The rest of the authors have no relevant financial disclosures.None. This study was exempt from institutional review board approval.

Figures

Fig. 1
Fig. 1
Summary of study selection according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines 36. We searched PubMed, Embase, and the Cochrane Database of Systematic Reviews for studies analyzing the effects of tranexamic use in patients who underwent pelvic and/or acetabular fracture surgery.
See this image and copyright information in PMC

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