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. 2021 Dec 1:11:622282.
doi: 10.3389/fonc.2021.622282. eCollection 2021.

Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis

Lu Zhou  1   2 , Wei-Ming Xiao  1   3 , Cheng-Peng Li  4 , Yi-Wen Gao  1   5 , Wei-Juan Gong  1   5 , Guo-Tao Lu  1   3
Affiliations

Impact of Fatty Pancreas on Postoperative Pancreatic Fistulae: A Meta-Analysis

Lu Zhou et al. Front Oncol. .

Abstract

Background: Soft pancreas is widely recognized as an important risk factor for the development of postoperative pancreatic fistula (POPF). Although fatty pancreas (FP) has not been formally defined as a cause of pancreatic fistula, existing research has shown that it can increase the incidence of POPF by increasing pancreatic tenderness; therefore, it may be a potential risk factor. This study aimed to discern whether FP was associated with POPF.

Method: Two reviewers independently performed literature searches from five electronic databases. According to the established inclusion criteria, we extracted necessary data from the studies that met the criteria for further analysis. We pooled the odds ratios (ORs) from individual studies using a random-effects model to investigate the associations between POPF and the prognosis of FP.

Result: A total of 11 studies involving 2484 individuals were included. The pooled prevalence of POPF was 18% (95% CI: 12-24%). Body mass index (BMI) was associated with a significantly increased risk of POPF (OR=3.55; 95% CI: 1.83, 6.86; P=0.0002; I²=0). FP was obviously associated with the occurrence of POPF (OR=3.75; 95% CI: 1.64, 8.58; P=0.002; I²=78).

Conclusion: FP is closely associated with the development of POPF, and the early identification of these high-risk patients can help to reduce the incidence of POPF.

Systematic review registration: The Registration URL link is (https://www.crd.york.ac.uk/PROSPERO/). The ID is "CRD42021265141".

Keywords: BMI - Body Mass Index; fatty pancreas; pancrea; pancreatic cancer; pancreatic fistula (PF).

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the study selection process.
Figure 2
Figure 2
Forest plots of POPF’s prevalence rate.
Figure 3
Figure 3
Forest plots of BMI on POFP.
Figure 4
Figure 4
Forest plots of the effect of FP on POPF.
Figure 5
Figure 5
Sensitivity analysis of the association Association Between FP and POPF.
See this image and copyright information in PMC

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