Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec 1:8:783831.
doi: 10.3389/fnut.2021.783831. eCollection 2021.

A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

Hongyun Lu  1 , Shengliang Zhang  1 , Jinling Wang  2 , Qihe Chen  1
Affiliations
Review

A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

Hongyun Lu et al. Front Nutr. .

Abstract

Recently, owing to well-controlled release, enhanced distribution and increased permeability, nanocarriers used for alternative drug and food-delivery strategies have received increasingly attentions. Nanocarriers have attracted a large amount of interest as potential carriers of various bioactive molecules for multiple applications. Drug and food-based delivery via polymeric-based nanocarriers and lipid-based nanocarriers has been widely investigated. Nanocarriers, especially liposomes, are more and more widely used in the area of novel nano-pharmaceutical or food-based design. Herein, we aimed to discuss the recent advancement of different surface-engineered nanocarriers type, along with cutting-edge applications for food and nanomedicine and highlight the alternative of phytochemical as nanocarrier. Additionally, safety concern of nanocarriers was also highlighted.

Keywords: drug and food application; lipid-based nanocarriers; nanoformulation; phytochemical; polymer-based nanocarriers.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Lipid and polymer-based nanocarrier systems.
Figure 2
Figure 2
The classification of nanocarriers based on lipids or phospholipids.
Figure 3
Figure 3
Different types of polymer-based nanocarriers.
See this image and copyright information in PMC

References

    1. Chen H, Gu Z, An H, Chen C, Chen J, Cui R, et al. . Precise nanomedicine for intelligent therapy of cancer. Sci China Chem. (2018) 61:1503–52. 10.1007/s11426-018-9397-5 - DOI
    1. Germain M, Caputo F, Metcalfe S, Tosi G, Spring K, Aslund AKO, et al. . Delivering the power of nanomedicine to patients today. J Control Release. (2020) 326:164–71. 10.1016/j.jconrel.2020.07.007 - DOI - PMC - PubMed
    1. Bordat A, Boissenot T, Nicolas J, Tsapis N. Thermoresponsive polymer nanocarriers for biomedical applications. Adv Drug Deliv Rev. (2019) 138:167–92. 10.1016/j.addr.2018.10.005 - DOI - PubMed
    1. Simon J, Christmann S, Mailänder V, Wurm FR, Landfester K. Protein corona mediated stealth properties of biocompatible carbohydrate-based nanocarriers. Isr J Chem. (2018) 58:1363–72. 10.1002/ijch.201800166 - DOI - PubMed
    1. Roberts TC, Langer R, Wood MJA. Advances in oligonucleotide drug delivery. Nat Rev Drug Discovery. (2020) 19:673–94. 10.1038/s41573-020-0075-7 - DOI - PMC - PubMed

LinkOut - more resources