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. 2022 Jan;11(1):5-6.
doi: 10.1002/psp4.12756. Epub 2022 Jan 3.

Reproducing prolonged time to peak bisoprolol concentration by PBPK modeling with lysosomal trapping in enterocytes

Affiliations

Reproducing prolonged time to peak bisoprolol concentration by PBPK modeling with lysosomal trapping in enterocytes

Dan-Na Wu et al. CPT Pharmacometrics Syst Pharmacol. 2022 Jan.
No abstract available

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Conflict of interest statement

The authors declared no competing interests for this work.

References

    1. Macwan JS, Fraczkiewicz G, Bertolino M, Krüger P, Peters SA. Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: the case of bisoprolol. CPT Pharmacometrics Syst Pharmacol. 2021;10(6):622‐632. - PMC - PubMed
    1. Li GF, Wang K, Chen R, Zhao HR, Yang J, Zheng QS. Simulation of the pharmacokinetics of bisoprolol in healthy adults and patients with impaired renal function using whole‐body physiologically based pharmacokinetic modeling. Acta Pharmacol Sin. 2012;33(11):1359‐1371. - PMC - PubMed
    1. Hansmann S, Darwich A, Margolskee A, Aarons L, Dressman J. Forecasting oral absorption across biopharmaceutics classification system classes with physiologically based pharmacokinetic models. J Pharm Pharmacol. 2016;68(12):1501‐1515. - PubMed
    1. Samant TS, Lukacova V, Schmidt S. Development and qualification of physiologically based pharmacokinetic models for drugs with atypical distribution behavior: a desipramine case study. CPT Pharmacometrics Syst Pharmacol. 2017;6(5):315‐321. - PMC - PubMed
    1. Peters SA, Hultin L. Early identification of drug‐induced impairment of gastric emptying through physiologically based pharmacokinetic (PBPK) simulation of plasma concentration‐time profiles in rat. J Pharmacokinet Pharmacodyn. 2008;35(1):1‐30. - PubMed

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