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Review
. 2021 Dec;37(12):1119-1124.
doi: 10.1051/medsci/2021204. Epub 2021 Dec 20.

[Extracellular vesicles and cardiovascular diseases]

[Article in French]
Pierre-Michael Coly  1 , Xavier Loyer  1
Affiliations
Free article
Review

[Extracellular vesicles and cardiovascular diseases]

[Article in French]
Pierre-Michael Coly et al. Med Sci (Paris). 2021 Dec.
Free article

Abstract
in English, French

Cardiovascular diseases remain the leading cause of death globally. There is therefore a need to develop new approaches for the treatment and early detection of these ailments. In the past decades, extracellular vesicles (EVs) have attracted significant attention as their role in intercellular communication has been brought to light. They have been shown to regulate pathways such as cellular inflammation or angiogenesis, and are therefore involved in key aspects of cardiovascular pathophysiology. Interestingly, EVs appear to have a multifaceted role which depends on their origin and cargo. Though at times deleterious, they have also been proposed as promising diagnostic tools and potential therapeutics. This review highlights recent advances in the role of extracellular vesicles in cardiovascular pathologies.

Title: Vésicules extracellulaires et maladies cardiovasculaires.

Abstract: Les maladies cardiovasculaires constituent la principale cause de décès dans le monde. Il est donc urgent de développer de nouvelles approches pour le traitement et la détection de ces maladies. Les vésicules extracellulaires (VE) ont attiré une attention considérable au vu de leur rôle dans la communication intercellulaire. Elles régulent en effet des processus clés comme l’inflammation ou l’angiogenèse, et sont donc impliquées dans de nombreux aspects de la physiopathologie cardiovasculaire. Les VE semblent avoir une action complexe qui dépend de leur origine et de leur contenu. Bien que leur présence soit parfois délétère, elles sont également considérées comme des outils diagnostiques et thérapeutiques potentiels. Cette revue résume les avancées récentes dans la compréhension du rôle des VE dans les maladies cardiovasculaires.

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