Detecting Keratoconus: Feasibility and Findings in Three Pediatric Risk Groups

Abstract

Purpose: To investigate the utility of three corneal screening devices in three groups of children.

Methods: This was a prospective study of patients with Trisomy 21 (group 1), patients with a first-degree relative with keratoconus (group 2), and control patients (group 3). Informed consent was obtained before testing with the Pentacam (Oculus Optikgeräte GmbH), Orbscan (Orbscan, Inc), and Ocular Response Analyzer (ORA) (Ametek Reichart Technologies). The ability to complete tests, the quality of results, and the corneal parameters obtained for each eye were recorded. A one-way analysis of variance test was used to compare the results between the three groups.

Results: Fifty-four patients aged from 7 to 17 years (mean: 11.74 years) were enrolled between July 2014 and July 2016. The number of patients and the percentage of tests completed for groups 1, 2, and 3 were 12 (55%), 21 (87%), and 21 (88%), respectively. The Pentacam values by group were central corneal thickness of 524, 543, and 542 µm (P = .36); thinnest point of 498, 536, and 534 µm (P = .03); corneal front mean keratometry of 44.9, 43.2, and 43.2 (P = .01); and quality score of 1.42, 0.22, and 0.04 (P < .0001), respectively. Orbscan values by group were central corneal thickness of 493, 551, and 550 µm (P = .01) and thinnest point of 451, 536, and 538 µm (P < .0001), respectively. ORA values by group were corneal hysteresis of 10.6, 12.1, and 11.6 (P = .124); corneal resistance factor of 9.9, 11.8, and 11.6 (P = .03); and waveform score of 5.6, 7.6, and 7.3 (P < .0001), respectively.

Conclusions: Patients in group 1 completed fewer tests reliably and had thinner corneas and lower corneal resistance factors than patients in groups 2 and 3. Corneal tests used to evaluate adults for keratoconus may not be reliable for the evaluation of certain high-risk pediatric patients. [J Pediatr Ophthalmol Strabismus. 2022;59(2):94-101.].