Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec 20;7(1):76.
doi: 10.1186/s40942-021-00348-y.

The effect of silicone oil tamponade on retinal layers and choroidal thickness in patients with rhegmatogenous retinal detachment: a systematic review and meta-analysis

Heshmatollah Ghanbari  1 , Farzan Kianersi  1 , Alireza Jamshidi Madad  1 , Alireza Dehghani  1 , Alireza Rahimi  2 , Awat Feizi  3 , Afsaneh Naderi Beni  4
Affiliations
Review

The effect of silicone oil tamponade on retinal layers and choroidal thickness in patients with rhegmatogenous retinal detachment: a systematic review and meta-analysis

Heshmatollah Ghanbari et al. Int J Retina Vitreous. .

Abstract

Background: To evaluate the effects of intravitreal silicone oil (SO) on the retinal and choroidal thickness in eyes with rhegmatogenous retinal detachment (RRD).

Methods: A literature search was performed in Web of Science, Scopus, ProQuest, Embase, Clinical Key, Science Direct, Cochrane Library, and Springer, as well as Persian databases, including IranDoc, MagIran, SID, MOH thesis, and MOH articles until June 2020. Two reviewers independently searched and extracted the data.

Results: Sixteen studies (n = 391) met the inclusion criteria. The meta-analysis showed that the SO tamponade could significantly reduce the central macular thickness (CMT) in patients with RRD as compared to gas tamponade WMD = - 14.91; 95% CI: - 22.23, - 7.60; P < 0.001, I2 = 71%). No significant change was found in CMT between the eye with SO tamponade (after SO removal) and the fellow healthy eye in patients with RRD (WMD = - 3.52; 95% CI: - 17.63, 10.59; I2 = 68.6%). Compared to the preoperative stage, the SO tamponade could significantly reduce the subfoveal choroidal thickness in patients with RRD (WMD = - 18.67, 95% CI: - 30.07, - 1.28; I2 = 80.1%). However, there was no significant difference in the subfoveal choroidal thickness before and after SO removal (WMD = - 1.13, 95% CI: - 5.97, 3.71; I2 = 87.6%).

Conclusion: The SO tamponade had a significant effect on the reduction of retinal layers and the subfoveal choroidal thickness.

Keywords: Choroidal thickness; Retinal layer thickness; Rhegmatogenous retinal detachment; Silicone oil.

PubMed Disclaimer

Conflict of interest statement

Authors do not have any financial interest in any products mentioned in this article. This study received no external funding. The author declares that he has no competing interest.

Figures

Fig. 1
Fig. 1
The results of the literature search strategy. The flow diagram depicts the screening process of articles and the number of exclusions
Fig. 2
Fig. 2
Effect of SO (silicone oil) tamponade on retinal layers in patients with rhegmatogenous retinal detachment (RRD). SO silicone oil, RRD rhegmatogenous retinal detachment, CMT central macular thickness, NFL nerve fiber layer, GCL ganglion cell layer, IPL inner plexiform layer, INL inner plexiform layer, OPL outer plexiform layer, ONL outer nuclear layer, RPE retinal pigment epithelium
Fig. 2
Fig. 2
Effect of SO (silicone oil) tamponade on retinal layers in patients with rhegmatogenous retinal detachment (RRD). SO silicone oil, RRD rhegmatogenous retinal detachment, CMT central macular thickness, NFL nerve fiber layer, GCL ganglion cell layer, IPL inner plexiform layer, INL inner plexiform layer, OPL outer plexiform layer, ONL outer nuclear layer, RPE retinal pigment epithelium
Fig. 2
Fig. 2
Effect of SO (silicone oil) tamponade on retinal layers in patients with rhegmatogenous retinal detachment (RRD). SO silicone oil, RRD rhegmatogenous retinal detachment, CMT central macular thickness, NFL nerve fiber layer, GCL ganglion cell layer, IPL inner plexiform layer, INL inner plexiform layer, OPL outer plexiform layer, ONL outer nuclear layer, RPE retinal pigment epithelium
Fig. 3
Fig. 3
Effect of SO tamponade on SFCT in patients with RRD. SO silicone oil, RRD rhegmatogenous retinal detachment, SFCT subfoveal choroidal thickness
See this image and copyright information in PMC

References

    1. Dehghani A, Razmjoo H, Fazel F, et al. The comparison of retinal blood flow after scleral buckling surgery with or without encircling procedure. J Res Med Sci. 2013;18(3):222. - PMC - PubMed
    1. Akhlaghi M, Zarei M, Ziaei M, et al. Sensitivity, specificity, and accuracy of color Doppler ultrasonography for diagnosis of retinal detachment. J Ophthalmic Vis Res. 2020;15(2):166. - PMC - PubMed
    1. Azen SP, Scott IU, Flynn HW, Jr, et al. Silicone oil in the repair of complex retinal detachments: a prospective observational multicenter study. Ophthalmology. 1998;105(9):1587–1597. doi: 10.1016/S0161-6420(98)99023-6. - DOI - PubMed
    1. Herbert EN, Laidlaw DAH, Williamson TH, et al. Loss of vision once silicone oil has been removed. Retina (Philadelphia, Pa) 2005;25(6):808–809. doi: 10.1097/00006982-200509000-00032. - DOI - PubMed
    1. Williams PD, Fuller CG, Scott IU, et al. Vision loss associated with the use and removal of intraocular silicone oil. Clin Ophthalmol (Auckland, NZ) 2008;2(4):955. - PMC - PubMed

LinkOut - more resources