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Case Reports
. 2021 Dec 20;14(12):e245187.
doi: 10.1136/bcr-2021-245187.

Ribociclib-associated organising pneumonia

Arjun Rajendran  1 , Akhilesh Kunoor  2 , Roshini Pushpa Ragahavan  1 , Pavithran Keechilat  3
Affiliations
Case Reports

Ribociclib-associated organising pneumonia

Arjun Rajendran et al. BMJ Case Rep. .

Abstract

A 63-year-old woman with grade 2 infiltrating left breast carcinoma who was started on ribociclib complained of exertional dyspnoea along with dry cough. There were bilateral interscapular crackles and chest X-ray evidence of bilateral mid and lower zone non-homogeneous opacity. The patient's pulmonary function test (PFT) showed moderate restrictions and desaturation. CT was suggestive of organising pneumonia and drug administration was stopped. The patient was treated with steroids in tapering doses, which led to improvements. The drug was restarted with the probability of other aetiologies for interstetial lung disease (ILD). It was also considered the superior efficacy of ribociclib in managing breast cancer. But due to evidence indicating the reappearance of organising pneumonia following drug administration, it was again stopped, and steroid use was restarted for treatment. The patient showed improvements in subsequent follow-ups.

Keywords: breast cancer; interstitial lung disease; pneumonia (respiratory medicine).

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Chest X-ray showing predominant bilateral mid and lower zone non-homogeneous opacity.
Figure 2
Figure 2
CT showing patchy subpleural airspace opacities with peribronchial dilation.
Figure 3
Figure 3
Serial X-ray showing resolving interstitial infiltrates.
Figure 4
Figure 4
Chest X-ray showing bilateral reticular opacities with GGO. GGO, ground glass opacity.
Figure 5
Figure 5
Reduction of lung parenchymal changes secondary to organising pneumonia.
Figure 6
Figure 6
Graphical representation of SpO2 showing increase in values during ribociclib stopped months.
Figure 7
Figure 7
Graphical representation of desaturation values. Desaturation values can be seen reducing in drug stopped months.
Figure 8
Figure 8
Graphical representation of DLCO values. Increase in the value can be seen in drug stopped months.
Figure 9
Figure 9
Graphical representation of PFT values. Increase in the value can be seen in drug stopped months.
See this image and copyright information in PMC

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