[Serum 5-nucleotidase activity in chronic hepatobiliary diseases]

Abstract

Serum activity of 5-H studied in 178 patients with chronic liver bile diseases: chronic hepatitis, liver cirrhosis, neoplasms of the liver and bile ducts, benign biliary diseases, chronic alcoholism, liver enzymopathies. Enzyme activity is elevated in all diseases but reaches its highest in the presence of biliary stasis. In comparison with APh, gamma-GTP, LAP and cholesterol the deviations of 5-H in biliary stasis are quantitatively better manifested. The diagnostic value (reliability) of six indices for the differential diagnosis of biliary stasis was studied. APh, 5-H, gamma-GTP have a high diagnostic sensitivity, whereas Lp-H, cholesterol and 5-H revealed a high specificity and the highest "predicting" value. The method used for the assessment of 5-H activity is distinguished for its reliable analytical qualities and is appropriate for routine labour diagnostics.