. 2022 May 16;225(10):1694-1700.

doi: 10.1093/infdis/jiab619.

Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

Nathaniel M Lewis¹, Eric A Naioti¹, Wesley H Self², Adit A Ginde³, David J Douin³, H Keipp Talbot², Jonathan D Casey², Nicholas M Mohr⁴, Anne Zepeski⁴, Manjusha Gaglani^{5

6}, Shekhar A Ghamande⁵, Tresa A McNeal⁵, Nathan I Shapiro⁷, Kevin W Gibbs⁸, D Clark Files⁸, David N Hager⁹, Arber Shehu⁹, Matthew E Prekker¹⁰, Heidi L Erickson¹⁰, Michelle N Gong¹¹, Amira Mohamed¹¹, Daniel J Henning¹², Jay S Steingrub¹³, Ithan D Peltan¹⁴, Samuel M Brown¹⁴, Emily T Martin¹⁵, Kinsley Hubel¹⁶, Catherine L Hough¹⁶, Laurence W Busse¹⁷, Caitlin C Ten Lohuis¹⁷, Abhijit Duggal¹⁸, Jennifer G Wilson¹⁹, Alexandra J Gordon¹⁹, Nida Qadir²⁰, Steven Y Chang²⁰, Christopher Mallow²¹, Carolina Rivas²¹, Hilary M Babcock²², Jennie H Kwon²², Matthew C Exline²³, Natasha Halasa², James D Chappell², Adam S Lauring²⁴, Carlos G Grijalva², Todd W Rice², Jillian P Rhoads², William B Stubblefield², Adrienne Baughman², Kelsey N Womack², Christopher J Lindsell², Kimberly W Hart², Yuwei Zhu², Stephanie J Schrag¹, Miwako Kobayashi¹, Jennifer R Verani¹, Manish M Patel¹, Mark W Tenforde¹; IVY Network Collaborators

Collaborators, Affiliations

Collaborators

IVY Network Collaborators:
Tresa McNeal, Shekhar Ghamande, Nicole Calhoun, Kempapura Murthy, Judy Herrick, Amanda McKillop, Eric Hoffman, Martha Zayed, Michael Smith, Natalie Settele, Jason Ettlinger, Elisa Priest, Jennifer Thomas, Alejandro Arroliga, Madhava Beeram, Ryan Kindle, Lori-Ann Kozikowski, Lesley De Souza, Scott Ouellette, Sherell Thornton-Thompson, Patrick Tyler, Omar Mehkri, Meg Mitchell, Connery Brennan, Kiran Ashok, Bryan Poynter, Nicholas Stanley, Audrey Hendrickson, Sean Caspers, Tyler Scharber, Jeffrey Jorgensen, Robert Bowers, Jennifer King, Valerie Aston, Brent Armbruster, Richard E Rothman, Rahul Nair, Jen-Ting Tina Chen, Sarah Karow, Emily Robart, Paulo Nunes Maldonado, Maryiam Khan, Preston So, Joe Levitt, Cynthia Perez, Anita Visweswaran, Jonasel Roque, Trevor Frankel, Omai Garner, Sukantha Chandrasekaran, Jennifer Goff, David Huynh, Adit Ginder, David Douin, Kelly Jensen, Conner Driver, Michael Carricato, Ian Chambers, Paul Nassar, Lori Stout, Zita Sibenaller, Alicia Walter, Jasmine Mares, Logan Olson, Bradley Clinansmith, Carolina Rivas, Hayley Gershengorn, E J McSpadden, Rachel Truscon, Anne Kaniclides, Lara Thomas, Ramsay Bielak, Weronika Damek Valvano, Rebecca Fong, William J Fitzsimmons, Christopher Blair, Andrew L Valesano, Julie Gilbert, Akram Khan, Olivia Krol, Zachary Zouyed, Emma Silverman, Genesis Briceno, Emmanuel Mills, Christine D Crider, Kyle A Steinbock, Thomas C Paulson, Layla A Anderson, Christy Kampe, Jakea Johnson, Rendie McHenry, Marcia Blair, Laura Short, Mary LaRose, Leigha Landreth, Madeline Hicks, Lisa Parks, Jahnavi Bongu, David McDonald, Candice Cass, Sondra Seiler, David Park, Tiffany Hink, Meghan Wallace, Carey-Ann Burnham, Olivia G Arter

Affiliations

¹ Centers for Disease Control and Prevention COVID-19 Response Team, Atlanta, Georgia, USA.
² Vanderbilt University Medical Center, Nashville, Tennessee, USA.
³ University of Colorado School of Medicine, Aurora, Colorado, USA.
⁴ University of Iowa, Iowa City, Iowa, USA.
⁵ Baylor Scott and White Health, Temple, Texas, USA.
⁶ Texas A&M University College of Medicine, Temple, Texas, USA.
⁷ Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
⁸ Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA.
⁹ Johns Hopkins Hospital, Baltimore, Maryland, USA.
¹⁰ Hennepin County Medical Center, Minneapolis, Minnesota, USA.
¹¹ Montefiore Healthcare Center, Albert Einstein College of Medicine, Bronx, New York, USA.
¹² University of Washington School of Medicine, Seattle, Washington, USA.
¹³ Baystate Medical Center, Springfield, Massachusetts, USA.
¹⁴ Intermountain Medical Center and University of Utah, Salt Lake City, Utah, USA.
¹⁵ University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
¹⁶ Oregon Health and Science University Hospital, Portland, Oregon, USA.
¹⁷ Emory University School of Medicine, Atlanta, Georgia, USA.
¹⁸ Cleveland Clinic, Cleveland, Ohio, USA.
¹⁹ Stanford University School of Medicine, Palo Alto, California, USA.
²⁰ David Geffen School of Medicine at University of California Los Angeles, Ronald Reagan-University of California Los Angeles Medical Center, Los Angeles, California, USA.
²¹ University of Miami, Miami, Florida, USA.
²² Washington University, St Louis, Missouri, USA.
²³ Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
²⁴ University of Michigan School of Medicine, Ann Arbor, Michigan, USA.

PMID: 34932114
PMCID: PMC9113447
DOI: 10.1093/infdis/jiab619

Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

Nathaniel M Lewis et al. J Infect Dis. 2022.

. 2022 May 16;225(10):1694-1700.

doi: 10.1093/infdis/jiab619.

Authors

Collaborators

IVY Network Collaborators:
Tresa McNeal, Shekhar Ghamande, Nicole Calhoun, Kempapura Murthy, Judy Herrick, Amanda McKillop, Eric Hoffman, Martha Zayed, Michael Smith, Natalie Settele, Jason Ettlinger, Elisa Priest, Jennifer Thomas, Alejandro Arroliga, Madhava Beeram, Ryan Kindle, Lori-Ann Kozikowski, Lesley De Souza, Scott Ouellette, Sherell Thornton-Thompson, Patrick Tyler, Omar Mehkri, Meg Mitchell, Connery Brennan, Kiran Ashok, Bryan Poynter, Nicholas Stanley, Audrey Hendrickson, Sean Caspers, Tyler Scharber, Jeffrey Jorgensen, Robert Bowers, Jennifer King, Valerie Aston, Brent Armbruster, Richard E Rothman, Rahul Nair, Jen-Ting Tina Chen, Sarah Karow, Emily Robart, Paulo Nunes Maldonado, Maryiam Khan, Preston So, Joe Levitt, Cynthia Perez, Anita Visweswaran, Jonasel Roque, Trevor Frankel, Omai Garner, Sukantha Chandrasekaran, Jennifer Goff, David Huynh, Adit Ginder, David Douin, Kelly Jensen, Conner Driver, Michael Carricato, Ian Chambers, Paul Nassar, Lori Stout, Zita Sibenaller, Alicia Walter, Jasmine Mares, Logan Olson, Bradley Clinansmith, Carolina Rivas, Hayley Gershengorn, E J McSpadden, Rachel Truscon, Anne Kaniclides, Lara Thomas, Ramsay Bielak, Weronika Damek Valvano, Rebecca Fong, William J Fitzsimmons, Christopher Blair, Andrew L Valesano, Julie Gilbert, Akram Khan, Olivia Krol, Zachary Zouyed, Emma Silverman, Genesis Briceno, Emmanuel Mills, Christine D Crider, Kyle A Steinbock, Thomas C Paulson, Layla A Anderson, Christy Kampe, Jakea Johnson, Rendie McHenry, Marcia Blair, Laura Short, Mary LaRose, Leigha Landreth, Madeline Hicks, Lisa Parks, Jahnavi Bongu, David McDonald, Candice Cass, Sondra Seiler, David Park, Tiffany Hink, Meghan Wallace, Carey-Ann Burnham, Olivia G Arter

Affiliations

¹ Centers for Disease Control and Prevention COVID-19 Response Team, Atlanta, Georgia, USA.
² Vanderbilt University Medical Center, Nashville, Tennessee, USA.
³ University of Colorado School of Medicine, Aurora, Colorado, USA.
⁴ University of Iowa, Iowa City, Iowa, USA.
⁵ Baylor Scott and White Health, Temple, Texas, USA.
⁶ Texas A&M University College of Medicine, Temple, Texas, USA.
⁷ Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
⁸ Wake Forest University Baptist Medical Center, Winston-Salem, North Carolina, USA.
⁹ Johns Hopkins Hospital, Baltimore, Maryland, USA.
¹⁰ Hennepin County Medical Center, Minneapolis, Minnesota, USA.
¹¹ Montefiore Healthcare Center, Albert Einstein College of Medicine, Bronx, New York, USA.
¹² University of Washington School of Medicine, Seattle, Washington, USA.
¹³ Baystate Medical Center, Springfield, Massachusetts, USA.
¹⁴ Intermountain Medical Center and University of Utah, Salt Lake City, Utah, USA.
¹⁵ University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
¹⁶ Oregon Health and Science University Hospital, Portland, Oregon, USA.
¹⁷ Emory University School of Medicine, Atlanta, Georgia, USA.
¹⁸ Cleveland Clinic, Cleveland, Ohio, USA.
¹⁹ Stanford University School of Medicine, Palo Alto, California, USA.
²⁰ David Geffen School of Medicine at University of California Los Angeles, Ronald Reagan-University of California Los Angeles Medical Center, Los Angeles, California, USA.
²¹ University of Miami, Miami, Florida, USA.
²² Washington University, St Louis, Missouri, USA.
²³ Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
²⁴ University of Michigan School of Medicine, Ann Arbor, Michigan, USA.

PMID: 34932114
PMCID: PMC9113447
DOI: 10.1093/infdis/jiab619

Abstract

Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.

Keywords: COVID-19; chronic medical conditions; preexisting conditions; vaccine effectiveness.

Published by Oxford University Press for the Infectious Diseases Society of America 2021.

PubMed Disclaimer

Figures

**Figure 1.**
Vaccine effectiveness by age group and number of chronic medical conditions. Adjusted vaccine effectiveness (VE) was estimated using logistic regression comparing odds of being fully vaccinated with an mRNA COVID-19 vaccine versus being unvaccinated, in case patients and control patients, using the equation VE = 100 × (1 − odds ratio). Overall VE by number of condition categories documented (0, 1, 2, or ≥ 3) was calculated by including an interaction term between vaccination status and number of condition categories. An additional model including a 3-way interaction between age, conditions, and vaccination status was included to calculate VE by number of condition categories within age groups. Models were additionally adjusted for date of hospital admission (biweekly intervals), US Department of Health and Human Services region of hospital, age (continuous), sex, and race/ethnicity (non-Hispanic white, non-Hispanic black, Hispanic of any race, non-Hispanic other, or unknown), and number of condition categories. VE point estimates are rounded to the nearest whole number. Error bars represent 95% confidence intervals.

See this image and copyright information in PMC

References

1. Centers for Disease Control and Prevention. COVID data tracker. https://covid.cdc.gov/covid-data-tracker/#datatracker-home. Accessed 28 September 2021.
1. Sadarangani M, Marchant A, Kollmann TR.. Immunological mechanisms of vaccine-induced protection against COVID-19 in humans. Nat Rev Immunol 2021; 21:475–84. - PMC - PubMed
1. Baden LR, El Sahly HM, Essink B, et al. . Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med 2021; 384:403–16. - PMC - PubMed
1. El Sahly H, Baden LR, Essink B, et al. . Efficacy of the mRNA-1273 SARS-CoV-2 vaccine at completion of blinded phase. N Engl J Med 2021; 385:1774–85. - PMC - PubMed
1. Self WH, Tenforde MW, Rhoads JP, et al. . Comparative effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) vaccines in preventing COVID-19 hospitalizations among adults without immunocompromising conditions—United States, March–August 2021. MMWR Morb Mortal Wkly Rep 2021; 70:1337–43. - PMC - PubMed

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Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

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Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021

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