doi: 10.1093/jac/18.supplement_e.9.
Mechanisms by which imipenem may overcome resistance in gram-negative bacilli
- PMID: 3493237
- DOI: 10.1093/jac/18.supplement_e.9
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Mechanisms by which imipenem may overcome resistance in gram-negative bacilli
J Antimicrob Chemother.
1986 Dec.
Abstract
Imipenem is one of the carbapenem class of new beta-lactam antibiotics. It is a potent antibacterial with a broad spectrum of activity. Against Gram-negative rods, it appears to be able to circumvent the classical resistance mechanisms by way of its high affinity for PBP 2 and its good penetration of the cell wall. Imipenem is stable to hydrolysis by the common plasmid-mediated beta-lactamases and is a potent inducer of, but stable to the action of, chromosomal beta-lactamases.
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