Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr;80(4):448-449.
doi: 10.1590/0004-282X-ANP-2021-0319.

Acute hemorrhagic leukoencephalitis Associated with COVID-19

Daniel Teixeira Dos Santos  1 , Wyllians Vendramini Borelli  1 , Clarissa Both Pinto  1 , Iuri Christmann Wawrzeniak  1 , Marino Muxfeldt Bianchin  1   2 , Juliana Avila Duarte  1   2   3
Affiliations

Acute hemorrhagic leukoencephalitis Associated with COVID-19

Daniel Teixeira Dos Santos et al. Arq Neuropsiquiatr. 2022 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict of interest: There is no conflict of interest to declare.

Figures

Figure 1
Figure 1. Hospital events timeline.
Figure 2
Figure 2. (A) Axial T1 spin eco (SE) showed central hypointense with peripheral hyperintense lesions on bilateral deep white matter with effacement of the lateral and third ventricles. (B) Coronal reconstruction of a volumetric T1 gradient-echo (GRE) showed central hypointense with peripheral hyperintense lesions on deep white matter. (C) Axial T1 SE showed two small hemorrhages on both cerebellar hemispheres (red arrows). (D) Diffusion-weighted imaging revealed possible restriction on bilateral deep white matter compatible with subacute hemorrhages. (E): Axial FLAIR at basal ganglia level showed hyperintensity lesions on bilateral deep white matter with surrounding edema. (F) Axial FLAIR at supraganglionic level showed extensive bilateral edema. (G): Axial T2* at basal ganglia level showed hyperintensity lesions on deep white matter with hypointensity due to subacute hemorrhages. (H) Axial T2* at lower basal ganglia level showed hyperintense lesions on bilateral deep white matter with hypointensity with blooming effect due to subacute hemorrhages and there was another small hemorrhage on the left temporal lobe.
See this image and copyright information in PMC

References

    1. Virhammar J, Kumlien E, Fällmar D, Frithiof R, Jackmann S, Sköld MK, et al. Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid. Neurology. 2020 Sep;95(10):445–449. doi: 10.1212/WNL.0000000000010250. - DOI - PMC - PubMed
    1. Varadan B, Shankar A, Rajakumar A, Subramanian S, Sathya AC, Hakeem AR, et al. Acute hemorrhagic leukoencephalitis in a COVID-19 patient — a case report with literature review. Neuroradiology. 2021 May;63(5):653–661. doi: 10.1007/s00234-021-02667-1. - DOI - PMC - PubMed

MeSH terms