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. 2022 Jan;28(1):219-223.
doi: 10.3201/eid2801.210403.

Transfusion-Transmitted Hepatitis A Virus, France, 2018

Caroline Lefeuvre, Caroline Lefort, Françoise Boyer, Sophie Le Cam, Lina Mouna, Anne-Marie Roque-Afonso, Hélène Le Guillou-Guillemette, Rafaël Mahieu

Transfusion-Transmitted Hepatitis A Virus, France, 2018

Caroline Lefeuvre et al. Emerg Infect Dis. 2022 Jan.

Abstract

We report a transfusion-transmitted hepatitis A virus infection in an immunocompromised patient in France, detected shortly after a transfusion of pathogen-reduced pooled platelets. This case raises questions about the efficacy of donor screening methods. Additional safety measures, such as routine donation screening, should be considered.

Keywords: 2018. Emerg Infect Dis. 2022 Jan [date cited]. https://doi.org/10.3201/eid2801.210403; Boyer F; France; Le Cam S; Lefort C; Mouna L; Roque-Afonso A-M; Suggested citation for this article: Lefeuvre C; blood donor; blood transfusion; et al. Transfusion-transmitted hepatitis A virus; hemovigilance; hepatitis A; hepatitis A virus; pathogen inactivation; screening; viruses.

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Figures

Figure 1
Figure 1
Timeline of events in blood donor and recipient in case of transfusion-transmitted HAV, France, 2018. The donor interview did not reveal any relevant HAV risk factors, including travel, food consumption, personal entourage cases, or unsafe sex practices. The donor was not vaccinated against HAV at the time of donation. The recipient was not vaccinated against HAV at the time of the transfusion; moreover, the recipient has not been vaccinated in postexposure after notification of fresh frozen plasma HAV positivity. The recipient interview reported no other risk factors for HAV, including travel, food consumption, personal entourage cases, and unsafe sex practices, with the exception of recent transfusion. HAV, hepatitis A virus.
Figure 2
Figure 2
Phylogenetic relationships of viral protein 1/2A sequences in case of transfusion-transmitted hepatitis A virus, France, 2018. Black diamond indicates the sequence from the blood donor; red diamond indicates sequence from the blood recipient. Scale bar indicates nucleotide variation.
See this image and copyright information in PMC

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