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Comment
. 2021 Dec 20;56(24):3307-3308.
doi: 10.1016/j.devcel.2021.12.003.

Clone competition as a mechanism to reduce tumor formation

Amelia Acha-Sagredo  1 , Ilaria Malanchi  2 , Francesca D Ciccarelli  3
Affiliations
Free article
Comment

Clone competition as a mechanism to reduce tumor formation

Amelia Acha-Sagredo et al. Dev Cell. .
Free article

Abstract

With age, clones carrying somatic mutations in well-known cancer driver genes progressively populate adult tissues, yet cancer transformation is rare. In a recent issue of Nature, Colom et al. showed that competition between mutated clones with different fitness could act as a tumor-protective mechanism.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Mutant clones in normal epithelium outcompete and eliminate emerging tumours.
    Colom B, Herms A, Hall MWJ, Dentro SC, King C, Sood RK, Alcolea MP, Piedrafita G, Fernandez-Antoran D, Ong SH, Fowler JC, Mahbubani KT, Saeb-Parsy K, Gerstung M, Hall BA, Jones PH. Colom B, et al. Nature. 2021 Oct;598(7881):510-514. doi: 10.1038/s41586-021-03965-7. Epub 2021 Oct 13. Nature. 2021. PMID: 34646013 Free PMC article.

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