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. 2022 Jan 7;33(13):10.1088/1361-6528/ac4520.
doi: 10.1088/1361-6528/ac4520.

Recent advances of biomaterials in stem cell therapies

Yonger Xue  1 , Rafia Baig  1 , Yizhou Dong  1   2   3   4   5   6
Affiliations

Recent advances of biomaterials in stem cell therapies

Yonger Xue et al. Nanotechnology. .

Abstract

Stem cells have been utilized as 'living drugs' in clinics for decades. Their self-renewal, differentiation, and immunomodulating properties provide potential solutions for a variety of malignant diseases and disorders. However, the pathological environment may diminish the therapeutic functions and survival of the transplanted stem cells, causing failure in clinical translation. To overcome these challenges, researchers have developed biomaterial-based strategies that facilitatein vivotracking, functional engineering, and protective delivery of stem cells, paving the way for next-generation stem cell therapies. In this perspective, we briefly overview different types of stem cells and the major clinical challenges and summarize recent progress of biomaterials applied to boost stem cell therapies.

Keywords: biomaterials; nanoparticles; stem cells.

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Conflict of interest statement

Conflict of interest

YD is a scientific advisory board member of Oncorus Inc. Other authors declare no conflict of interest.

Figures

Figure 1.
Figure 1.
Schematic illustration of biomaterials-based strategies for enhancing stem cell therapy. Created with BioRender.com.
See this image and copyright information in PMC

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