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. 2022 Nov;36(21):5524-5529.
doi: 10.1080/14786419.2021.2018589. Epub 2021 Dec 21.

δ-Tocopherol derivatives from the leaves of Muntingia calabura L

Truong Nhat Van Do  1   2 , Tho Huu Le  1   2 , Hai Xuan Nguyen  1   2 , Trang Ngoc Tran Vo  1   2 , Phu Hoang Dang  1   2 , Nhan Trung Nguyen  1   2   3 , Mai Thanh Thi Nguyen  1   2   3
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δ-Tocopherol derivatives from the leaves of Muntingia calabura L

Truong Nhat Van Do et al. Nat Prod Res. 2022 Nov.

Abstract

From an ethyl acetate-soluble fraction of the leaves of Muntingia calabura, one new trimeric δ-tocopherol derivative named as tocomuntin A (1), together with three known δ-tocopherol derivatives (2-4) were isolated. Their structures were elucidated based on the interpretation of NMR and MS spectroscopic data. In this work, δ-tocopherol (3) was found to have α-glucosidase inhibitory activity for the first time (IC50, 47.3 μM).

Keywords: Muntingia calabura L. leaves; α-glucosidase inhibitory; δ-tocopherol.

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