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. 2021 Dec 14:14:9707-9718.
doi: 10.2147/IJGM.S339946. eCollection 2021.

Global Hotspots and Prospects of I-131 Therapy in Thyroid Carcinoma via Bibliometric Analysis

Shang Lin  1 , Ya-Ru Wei  2 , Hong-Xiang Yao  3
Affiliations

Global Hotspots and Prospects of I-131 Therapy in Thyroid Carcinoma via Bibliometric Analysis

Shang Lin et al. Int J Gen Med. .

Abstract

Background: Hundreds of studies have reported the application of iodine-131 (I-131) in thyroid carcinoma (THCA) in past years. However, the status of research in the field and other related topics have not been investigated. This study aimed to identify the cooperation of authors, countries, and institutions, as well as explore the hot topics and prospects regarding I-131 therapy in THCA based on previous studies.

Methods: Publications from 2010 to 2020 were retrieved from Web of Science Core Collection according to research strategy. Bibliometric analyses were performed using VOSviewer 1.6.15 and CiteSpace 5.7.3 to evaluate and visualize the cooperation network, hot topic, and research frontier.

Results: The number of publications showed a trend of fluctuation between 2010 and 2020. We identified 1387 publications related to I-131 therapy in THCA, which were published by 1628 institutions from 82 countries. The largest proportion of publications were emanated from the USA, and the majority of papers were published by Thyroid. Shanghai Jiao Tong University of China contributed the most papers. Although many authors participated in the research of this field, high-yield authors were few. Co-occurrence analysis classified keywords into five clusters, including assessment, efficacy measurement, monitoring, hormone regulation, and guidelines of I-131 therapy. The terms "bone marrow dosimetry and time" were among the latest hotspots. The research frontier topic in I-131 therapy focused on the "P53 and anti-Müllerian hormone".

Conclusion: The attention to I-131 therapy in THCA should be increased considerably. It was necessary to construct active co-operations between authors, countries, and institutions to promote the development of this field. Recent researches referred to the timing and dose assessment of I-131 therapy in THCA. Future studies likely focused on targeted therapy and adverse effects evaluation were worthy of research as well.

Keywords: I-131; bibliometric analysis; hot spots; research trend; thyroid carcinoma.

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Conflict of interest statement

The authors report no conflicts of interest for this work.

Figures

Figure 1
Figure 1
The annual publication about I-131 therapy in thyroid carcinoma during 2010–2020.
Figure 2
Figure 2
Collaboration network between journals. (A) Productive journals. (B) The top 10 journals.
Figure 3
Figure 3
Collaboration network maps. (A) Country. (B) Institution. (C) Author.
Figure 4
Figure 4
The keywords co-occurrence network. (A) Network visualization. The minimum number of occurrences of a keyword=30. Each color represented a cluster of the keyword. red: Cluster 1 (n=21), green: Cluster 2 (n=12), blue: Cluster 3 (n=8), yellow: Cluster 4 (n=7), purple: Cluster 5 (n=2). (B) Overlay visualization.
Figure 5
Figure 5
Top 24 keywords with the strongest citation bursts. The red bars meant the keywords occurred frequently. A greater strength indicated a higher frequency of occurrence.
Figure 6
Figure 6
Time-based visualization of keywords indicated the research trend. The “+” represented keywords and larger size indicated a higher occurrence frequency of keywords. The links represented the co-occurrence of keywords.
See this image and copyright information in PMC

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