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Review
. 2021 Dec 12:2021:3420168.
doi: 10.1155/2021/3420168. eCollection 2021.

Differences of Key Proteins between Apoptosis and Necroptosis

Min Yeong Park  1 , Sang Eun Ha  1 , Preethi Vetrivel  1 , Hun Hwan Kim  1 , Pritam Bhangwan Bhosale  1 , Abuyaseer Abusaliya  1 , Gon Sup Kim  1
Affiliations
Review

Differences of Key Proteins between Apoptosis and Necroptosis

Min Yeong Park et al. Biomed Res Int. .

Abstract

Many different types of programmed cell death (PCD) have been identified, including apoptosis and necroptosis. Apoptosis is a type of cell death that is controlled by various genes. It is in charge of eliminating aberrant cells such as cancer cells, replenishing normal cells, and molding the body as it develops. Necroptosis is a type of programmed cell death that combines necrosis and apoptosis. In other words, it takes on a necrotic appearance, although cells die in a controlled manner. Various investigations of these two pathways have revealed that caspase-8, receptor-interacting serine/threonine-protein kinase 1 (RIPK1), and RIPK3 are crucial proteins in charge of the switching between these two pathways, resulting in the activation or inhibition of necroptosis. In this review, we have summarized the key proteins between apoptosis and necroptosis.

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Conflict of interest statement

The authors clearly declare that they have no conflict of interest in this study.

Figures

Figure 1
Figure 1
Apoptosis and necroptosis pathways. Among the pathways of apoptosis and necroptosis, activation and inhibition are explained with a focus on caspase-8.
Figure 2
Figure 2
Necrosome and ripoptosome. (a) When complex I is activated by stimulation, complex II is formed and RIPK1 is dissociated. (b) When cIAPs block the ripoptosome, RIPK1 is isolated.
Figure 3
Figure 3
CASP8, RIPK1, and RIPK3 effect on apoptosis and necroptosis. Caspase-8 plays a role in apoptosis and necroptosis. In apoptosis, caspase-3 is cleaved to cause apoptosis, and in necroptosis, RIPK1 is inhibited to prevent necroptosis.
See this image and copyright information in PMC

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