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. 2022 Aug;35(4):739-747.
doi: 10.1111/jhn.12984. Epub 2022 Jan 18.

Genetic polymorphisms are not associated with energy intake 1 year after Roux-en-Y gastric bypass in women

Patrícia Fatima Sousa Novais  1 , Alex Harley Crisp  2 , Vania Aparecida Leandro-Merhi  3 , Renata Maria Galvão Cintra  1 , Irineu Rasera Jr  4 , Maria Rita Marques de Oliveira  1
Affiliations

Genetic polymorphisms are not associated with energy intake 1 year after Roux-en-Y gastric bypass in women

Patrícia Fatima Sousa Novais et al. J Hum Nutr Diet. 2022 Aug.

Abstract

Background: The present study aimed to investigate the influence of food intake on body weight loss (WL) and the association of gene polymorphisms, 1 year after Roux-en-Y gastric bypass (RYGB) surgery.

Methods: In total, 95 obese women (age ranged 20-50 years) in a Brazilian cohort underwent RYGB surgery and completed the study. Anthropometric measurements and food intake were assessed before and 1 year after surgery. Twelve gene polymorphisms (GHRL rs26802; GHSR rs572169; LEP rs7799039; LEPR rs1137101; 5-HT2C rs3813929; UCP2 rs659366; UCP2 rs660339; UCP3 rs1800849; SH2B1 rs7498665; TAS1R2 rs35874116; TAS1R2 rs9701796; and FTO rs9939609) were determined using a real-time polymerase chain reaction and a TaqMan assay. The subjects were divided into quartiles regarding percentage of excess weight loss (%EWL). The effect of genetic variants on energy and macronutrient intake was evaluated by simple logistic regression, followed by multiple logistic regression.

Results: Subjects in the first and second quartiles showed a higher initial body mass index. Energy and macronutrient intake before and 1 year after RYGB surgery did not differ between the %EWL quartiles. None of gene polymorphisms investigated showed an association with the estimated energy intake 1 year after surgery.

Conclusions: In conclusion, the estimate energy and food intake did not predict a greater body WL 1 year after RYGB surgery. In addition, the 12 gene polymorphism investigated did not affect the energy intake among female patients.

Keywords: bariatric surgery; food intake; gene polymorphism; obesity.

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